3tl5

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'''Unreleased structure'''
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[[Image:3tl5.jpg|left|200px]]
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The entry 3tl5 is ON HOLD until Paper Publication
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{{STRUCTURE_3tl5| PDB=3tl5 | SCENE= }}
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Authors: Murray, J.M., Wiesmann, C.
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===Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer===
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Description: Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer
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{{ABSTRACT_PUBMED_21981714}}
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==About this Structure==
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[[3tl5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TL5 OCA].
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==Reference==
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<ref group="xtra">PMID:021981714</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
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[[Category: Murray, J M.]]
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[[Category: Wiesmann, C.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 08:26, 2 November 2011

Image:3tl5.jpg

Template:STRUCTURE 3tl5

Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer

Template:ABSTRACT PUBMED 21981714

About this Structure

3tl5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sutherlin DP, Bao L, Berry M, Castanedo G, Chuckowree I, Dotson J, Folks A, Friedman L, Goldsmith R, Gunzner J, Heffron T, Lesnick J, Lewis C, Mathieu S, Murray J, Nonomiya J, Pang J, Pegg N, Prior WW, Rouge L, Salphati L, Sampath D, Tian Q, Tsui V, Wan NC, Wang S, Wei B, Wiesmann C, Wu P, Zhu BY, Olivero A. Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer. J Med Chem. 2011 Oct 7. PMID:21981714 doi:10.1021/jm2009327

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