Tyrosine phosphatase

From Proteopedia

Revision as of 07:36, 3 November 2011

Template:STRUCTURE 1q6j

Tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP.

3D Structures of tyrosine phosphatase

Class I

1a5y, 2hnp, 2hnq, 1oem, 1oeo, 1oes, 1oet, 1oeu, 1oev, 1sug, 2cm2, 2cm3, 3eu0, 3i80, 3a5j - hPTP-b catalytic domain – human
1gfy, 1i57, 1pa1, 2f6f, 3a5k, 3zv2 - hPTP-b catalytic domain (mutant)
1ptt, 1ptu, 1g1f, 1g1g, 1g1h, 1een, 1eeo - hPTP-b catalytic domain (mutant) + peptide
3i7z - hPTP-b catalytic domain + peptide
1ptv, 1pty - hPTP-b catalytic domain (mutant) + phosphotyrosine
1aax - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane
1ecv, 1c83, 1c84, 1c85, 1c86, 1c87, 1c88, 1g7f, 1g7g, 1jf7, 1l8g, 1kak, 1kav, 1lqf, 1nl9, 1nny, 1no6, 1nz7, 1ony, 1onz, 1ph0, 1pxh, 1pyn, 1q1m, 1q6j, 1q6m, 1q6n, 1q6p, 1q6s, 1q6t, 1qxk, 1t48, 1t49, 1t4j, 1xbo, 1wax, 2bgd, 2bge, 2azr, 2b07, 2f6t, 2f6v, 2f6w, 2f6y, 2f6z, 2f70, 2f71, 2fjn, 2cm7, 2cm8, 2cma, 2cmb, 2cmc, 2h4g, 2h4k, 2hb1, 2cne, 2cnf, 2cng, 2cnh, 2cni, 2nt7, 2nta, 2veu, 2vev, 2vew, 2vex, 2vey, 2qbp, 2qbq, 2qbr, 2qbs, 3cwe, 3d9c, 2zmm, 2zn7, 3eax, 3eb1, 3sme - hPTP-b catalytic domain + inhibitor
1nwl, 1nwe, 2fjm - hPTP-b catalytic domain (mutant) + inhibitor
2b4s - hPTP-b catalytic domain + insulin receptor
1wch – hPTP-e
3pdz - hPTP-e PDZ2 domain – NMR
1gm1 - mPTP-BL PDZ2 domain – mouse – NMR
1ozi - mPTP-BL PDZ2 domain (mutant) – NMR
3rgo – mPTP-1
3rgq – mPTP-1 + Pi(5)P

1gwz, 2b3o – hPTP SHP-1 catalytic domain
1x6c - hPTP SHP-1 SH2 domain – NMR

2b49 – hPTPN3 catalytic domain

2i75 – hPTPN4
2cs5 – hPTPN4 PDZ domain – NMR
2vph - hPTPN4 PDZ domain
3nfk, 3nfl - hPTPN4 PDZ domain + peptide

2bij – hPTPN5 catalytic domain
2bv5 - hPTPN5 catalytic domain (mutant)
2cjz - hPTPN5 catalytic domain (mutant) + phosphotyrosine

3ps5 – hPTPN6 (mutant)
2yu7, 2rmx – hPTPN6 SH2 domain + peptide – NMR

2a3k, 1zc0 – hPTPN7 catalytic domain
2gp0, 2hvl, 2qdc, 2qdm, 2qdp, 2qds, 2qdt, 2qdu – hPTPN7 catalytic domain (mutant)
2gph - hPTPN7 catalytic domain (mutant) + MAPK2
3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide

2pa5 – hPTPN9 catalytic domain

3b7o - hPTPN11 catalytic domain
3o5x – hPTPN11 catalytic domain + inhibitor
3tl0, 3tkz – hPTPN11 SH2 domain + peptide
3mow - hPTPN11 catalytic domain + tautomycetin analog

3lnx – hPTPN13 PDZ2 domain
3lny - hPTPN13 PDZ2 domain + peptide

2bzl – hPTPN14 catalytic domain

2p6x, 2qcj, 3h2x – hPTPN22 catalytic domain
2qct – hPTPN22 catalytic domain + inhibitor
3brh, 3olr - hPTPN22 catalytic domain + peptide
3omh - hPTPN22 catalytic domain (mutant) + peptide

3rau - hPTPN23 His domain

1xm2 – hPTP PRL-1
1r6h, 1v3a – hPTP IVA-3 – NMR
1rxd - hPTP IVA-1
1zck, 1x24 – rPTP 4A1 – rat
3i36 – rPTP-η catalytic domain
1zcl - rPTP 4A1 (mutant) + sulfate
3rz2 - rPTP 4A1 + peptide
1yts - YePTP catalytic domain (mutant) – Yersinia enterocolitica
1huf, 1k46 - YePTP N terminal domain
2y2f - YePTP catalytic domain + inhibitor
1c0e – bPTP (mutant) – bovine
1d1p – yPTP - yeast
1g4w – StPTP – Salmonella typhimurium
2i6i, 3ro1 – SsPTP – Sulfolobus solfataricus
2pi7 – cPTP CRYP-2 catalytic domain
2z72 – PTP residues 22-361 – Shewanella
3js5, 3jvi – EhPTP – Entamoeba histolytica
1fpr - hPTP SHP-1 catalytic domain + peptide
1ypt, 1ytw – YePTP catalytic domain + WO4
1ytn - YePTP catalytic domain + NO3
1lyv - YePTP catalytic domain (mutant) + phosphate
1pa9 - YePTP catalytic domain (mutant) + inhibitor
1qz0, 1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
1m0v - YePTP N terminal domain + peptide - NMR
1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
1dg9 – bPTP + HEPES
1d2a – yPTP + adenine
1d1q – yPTP (mutant) + PNPP
1g4u – StPTP + RAS-related C3 botulinum toxin substrate
1jyo – StPTP + secretion chaperone SICP
2dxp, 2i6o – SsPTP (mutant) + peptide
2i6p - SsPTP (mutant) + PNPP
2i6j – SsPTP + phosphate
2i6m – SsPTP + WO4
3ido – EhPTP + HEPES

Receptor PTP

1yfo – mRPTP-α catalytic domain
1p15 - mRPTP-α D2 domain

2ahs – hRPTP-β
2i3r, 2i5x - hRPTP-β catalytic domain
2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
2h03 - hRPTP-β catalytic domain (mutant) + inhibitor

2h4v, 2pbn – hRPTP-γ residues 831-1127
2hy3 - hRPTP-γ residues 819-1130 + VO4
2nlk - hRPTP-γ catalytic domain
3jxg - mRPTP-γ CA-like domain
3kld - mRPTP-γ CA-like domain + contactin 4
3jxh - hRPTP-γ CA-like domain

1x5z - hRPTP-δ fibronectin type-III domain – NMR
2dlh - hRPTP-δ FN3 domain – NMR
2yd6, 2yd7 - hRPTP-δ Ig1-2 domain

2jjd - hRPTP-ε residues 107-697

2c7s - hRPTP-κ residues 865-1154

1rpm - hRPTP-μ catalytic domain
2c9a - hRPTP-μ MAM-IG module
2v5y - hRPTP-μ extracellular region

2g59, 2gjt - hRPTP-ο catalytic domain

2cfv – hRPTP-η residues 1019-1311
2nz6 - hRPTP-η residues 1019-1311 (mutant)
2dle - hRPTP-η FN3 domain – NMR

2fh7 - hRPTP-σ catalytic domain (mutant)
2yd9 - hRPTP-σ Ig1-3 domain (mutant)
2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
2yd4 - cRPTP-σ Ig1-2 domain – chicken

3jxf - hRPTP-ζ CA-like domain
3s97 - hRPTP-ζ CA-like domain + congtactin Ig domains

1jln, 2a8b - mRPTP-R catalytic domain
2edx - hRPTP-F fibronectin type-III domain – NMR
1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide
2yd1, 2yd2 – DmRPTP Ig1-2 domain – Drosophila melanogaster
3s3e – DmRPTP-10D catalytic domain
3s3f - DmRPTP-10D catalytic domain + VO4
3s3h - DmRPTP-10D catalytic domain + peptide
3s3k - DmRPTP-10D catalytic domain + inhibitor

Dual-specificity PTP

1t3k – PTP (mutant) – Arabidopsis thaliana
2wgp – hPTP-14 residues 2-191

Class II – Low molecular weight PTP

1p8a – PTP (mutant) – Tritrichomonas foetus – NMR
2cwd – PTP – Thermus thermophilus
1phr - bPTP
3rof – PTP-A + peptide – Staphylococcus aureus

Class III – CDC25

1c25 – hCDC25A catalytic domain (mutant)
1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
1cwr - hCDC25B catalytic domain + WO4
1cwt - hCDC25B catalytic domain + Methyl-Hg
3op3 – hCDC25C residues 270-462

T-cell PTP

1l8k – hTC-PTP