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Acid phosphatase

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(New page: '''Acid phosphatase''' (ACP) is an enzyme which removes phosphate<br /> from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol...)
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{{STRUCTURE_1q1p| PDB=1q1p | SIZE=300| SCENE=Cadherin/Cv/1 |right|CAPTION=Cadherin, [[1q1p]] }}
'''Acid phosphatase''' (ACP) is an enzyme which removes phosphate<br /> from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate<br />. It is found in increased amounts in patients who have prostate<br /> cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.
'''Acid phosphatase''' (ACP) is an enzyme which removes phosphate<br /> from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate<br />. It is found in increased amounts in patients who have prostate<br /> cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.
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== 3D Structures of acid phosphatase ==
[[1qfx]] – ACP – ''Aspergillus niger''<br />
[[1qfx]] – ACP – ''Aspergillus niger''<br />
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[[1ute]] – PAP + μ-oxo-diiron – pig<br />
[[1ute]] – PAP + μ-oxo-diiron – pig<br />
[[1xzw]] - PAP + Fe + Mn + phosphate – sweet potato
[[1xzw]] - PAP + Fe + Mn + phosphate – sweet potato
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[[Category:Topic Page]]

Revision as of 11:51, 3 November 2011

Template:STRUCTURE 1q1p

Acid phosphatase (ACP) is an enzyme which removes phosphate
from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate
. It is found in increased amounts in patients who have prostate
cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.

Contents

3D Structures of acid phosphatase

1qfx – ACP – Aspergillus niger
1dkm, 1dkn – EcACP (mutant) + Hg – Escherichia coli
1dkl – EcACP
1n8n – EcACP-B + Au3
1n9k, 3cz4 - EcACP-B + Mg
1rmt - EcACP-B + adenosine + Mg
1rmq - EcACP-B + Co + Os
1dko - EcACP (mutant) + Hg + WO4
2heg - EcACP-B + Mg + aspartate-BeF3
2hf7 - EcACP-B + Mg + AlF3
1d2t - EbACP – Escherichia blattae
1iw8 - EbACP (mutant)
1eoi – EbACP + MoO4
2akc - StACP-A + WO4 - Salmonella typhimurium
2p4u – ACP1 + phosphate – mouse
2i33 – BaACP-C + Mg – Bacillus anthracis
2i34 - BaACP-C + Mg + WO4
3pct – ACP-C – Pasteurella multocida

Acid phosphatase complex with phosphate derivative

2b82 - EcACP-B + adenosine + Mg + phosphate
2b8j - EcACP-B + adenosine + Mg + spermine + Au3 + phosphate
1rmy - EcACP-B + Mg + deoxycytidine + phosphate
2g1a - EcACP-B + Mg + phosphonic acid derivative
1dkp, 1dkq - EcACP (mutant) + Hg + inositol hexakisphosphate
2a96 – StACP-A + phosphate

Histidine acid phosphatase

2d1g – FtHAP-A + VO4 – Francisella tularensis
2ipb - FtHAP-A (mutant)
3it0 - FtHAP-A + phosphate
3it1 - FtHAP-A + tartrate
3it2 - FtHAP-A
3it3 - FtHAP-A (mutant) + 3’- AMP

Prostate acid phosphatase

1rpa – rPSAP + tartaric acid – rat
1rpt – rPSAP + VO4
2hpa – hPSAP + propyl tartramic acid – human
1cvi – hPSAP
1nd5, 1nd6 – hPSAP + inhibitor

Purple acid phosphatase

1kbp, 2qfp, [[2qfr – PvPAP + Fe + Zn – Phaseolus vulgaris
3kbp - PvPAP + Fe + Zn + WO4
4kbp - PvPAP + Fe + Zn + phosphate
1qhw - rPAP + Fe + Zn
1qfc - rPAP + Fe + phosphate
1war – hPAP + Fe + phosphate
2bq8 - hPAP + Fe + Zn
1ute – PAP + μ-oxo-diiron – pig
1xzw - PAP + Fe + Mn + phosphate – sweet potato

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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