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Sandbox 47
From Proteopedia
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<StructureSection load='1hpl' size='500' side='right' caption='Structure of Lipase (PDB entry [[1hpl]])' scene=''> | <StructureSection load='1hpl' size='500' side='right' caption='Structure of Lipase (PDB entry [[1hpl]])' scene=''> | ||
== '''Introduction''' == | == '''Introduction''' == | ||
| - | Pancreatic <scene name='Sandbox_47/Lipase/1'>lipase</scene> is secreted from the pancreas and is the primary enzyme that breaks down lipids in the digestive system. | + | Pancreatic <scene name='Sandbox_47/Lipase/1'>lipase</scene> (EC 3.1.1.3) is secreted from the pancreas and is the primary enzyme that breaks down lipids in the digestive system. It converts triglyceride substrates to monoglycerides and free fatty acids. <ref>"Pancreatic lipase". Wikipedia: The Free Encyclopedia. 7 Nov 2011 [http://en.wikipedia.org/wiki/Pancreatic_lipase]</ref> |
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== '''Structure''' == | == '''Structure''' == | ||
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== '''Function''' == | == '''Function''' == | ||
| - | + | Unlike many proteases, pancreatic lipase is secreted in its final form. However, it is only active in the presence of colipase in the duodenum. Colipase is also secreted in the pancreas, but in its inactive form, procolipase, which is activated by trypsin in the intestinal lumen. Colipase prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.<ref>"Colipase". Wikipedia: The Free Encyclopedia. 5 July 2011 [http://en.wikipedia.org/wiki/Colipase]</ref> | |
== '''References''' == | == '''References''' == | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 00:52, 10 November 2011
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Lipase
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