User:Udayan Shevade/Sandbox1
From Proteopedia
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| - | The monomer of the helicase contains a AAA+ domain. Each monomer binds and hydrolyzes an ATP to drive an overall change in | + | The monomer of the helicase contains a AAA+ domain. Each monomer binds and hydrolyzes an ATP to drive an overall conformational change in the hexamer. |
Revision as of 04:28, 11 November 2011
SV40 Large T Antigen
Introduction
The SV40 large T antigen is a multifunctional regulatory protein encoded by Simian Virus 40, belonging to the AAA+ family of helicases [1]. It is responsible for initiation of DNA replication, regulation of transcription and alteration of the host cell cycle to promote infectivity. Large T antigen is an early gene product of SV40 and is translated via differential mRNA splicing.
Structure
T-antigen consists of an N-terminal J domain, a central origin-binding domain, and a C-terminal helicase domain [1].
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