1ux6
From Proteopedia
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| - | [[Image:1ux6.jpg|left|200px]]<br /><applet load="1ux6" size=" | + | [[Image:1ux6.jpg|left|200px]]<br /><applet load="1ux6" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ux6, resolution 1.90Å" /> | caption="1ux6, resolution 1.90Å" /> | ||
'''STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS'''<br /> | '''STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UX6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1UX6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UX6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: l-type lectin]] | [[Category: l-type lectin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:08:58 2008'' |
Revision as of 08:08, 3 February 2008
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STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS
Contents |
Overview
Thrombospondins (TSPs) are extracellular regulators of cell-matrix, interactions and cell phenotype. The most highly conserved region of all, TSPs are the calcium-binding type 3 (T3) repeats and the C-terminal, globular domain (CTD). The crystal structure of a cell-binding TSP-1, fragment, spanning three T3 repeats and the CTD, reveals a compact, assembly. The T3 repeats lack secondary structure and are organised around, a core of calcium ions; two DxDxDGxxDxxD motifs per repeat each, encapsulate two calcium ions in a novel arrangement. The CTD forms a, lectin-like beta-sandwich and contains four strictly conserved, calcium-binding sites. Disruption of the hairpin structure of T3 repeats 6, and 7 decreases protein secretion and stability. The availability for cell, attachment of an RGD motif in T3 repeat 7 is modulated by calcium loading., The central architectural role of calcium explains how it is critical for, the functions of the TSP C-terminal region. Mutations in the T3 repeats of, TSP-5/COMP, which cause two human skeletal disorders, are predicted to, disrupt the tertiary structure of the T3-CTD assembly.
Disease
Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[604714]
About this Structure
1UX6 is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats., Kvansakul M, Adams JC, Hohenester E, EMBO J. 2004 Mar 24;23(6):1223-33. Epub 2004 Mar 11. PMID:15014436
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