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Sandbox 34
From Proteopedia
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<StructureSection load='9pap' size='500' side='right' caption='Structure of 9PAP (PDB entry [[9pap]])' scene='Sandbox_34/9pap_without_solvent_meoh/3'> | <StructureSection load='9pap' size='500' side='right' caption='Structure of 9PAP (PDB entry [[9pap]])' scene='Sandbox_34/9pap_without_solvent_meoh/3'> | ||
| - | '''Papain''' is a cysteine protease from the peptidase C1 family. | + | '''Papain''' is a cysteine protease, also known as '''papaya proteinase I''',from the peptidase C1 family. Naturally found in the latex of the papaya fruit, one of the most common uses of papain is as a meat tenderizer because of its ability to hydrolyze specific peptide bonds. Another common use is as a digestive aid, again because of its ability to hydrolyze peptide bonds. Papaya is commonly referenced as a preferred fruit for those suffering from gastroesophageal reflux disease due to its ability to help the the stomach with digestion of complex proteins. |
| + | </StructureSection> | ||
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| + | == Structure == | ||
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| + | <StructureSection load='9pap' size='500' side='left' caption='Structure of 9PAP (PDB entry [[9pap]])' scene='Sandbox_34/9pap_without_solvent_meoh/3'> | ||
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| + | Papain is a relatively simple enzyme. It consists of only one chain of 212 residues with three disulfide bonds.<ref>PMID:6502713</ref> A modified cysteine residue with a sulhydryl group, <scene name='Sandbox_34/Entire_protein_with_ocs_focus/2'>cysteine sulfonic acid</scene>, is necessary for the activity of the enzyme.<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> | ||
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<scene name='Sandbox_34/9pap_without_ligands_bound/1'>TextToBeDisplayed</scene> | <scene name='Sandbox_34/9pap_without_ligands_bound/1'>TextToBeDisplayed</scene> | ||
<scene name='Sandbox_34/9pap_without_solvent_meoh/2'>TextToBeDisplayed</scene> | <scene name='Sandbox_34/9pap_without_solvent_meoh/2'>TextToBeDisplayed</scene> | ||
<scene name='Sandbox_34/Entire_protein_with_ocs_focus/1'>TextToBeDisplayed</scene> | <scene name='Sandbox_34/Entire_protein_with_ocs_focus/1'>TextToBeDisplayed</scene> | ||
<scene name='Sandbox_34/Entire_protein_with_ocs_focus/2'>TextToBeDisplayed</scene> | <scene name='Sandbox_34/Entire_protein_with_ocs_focus/2'>TextToBeDisplayed</scene> | ||
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== References == | == References == | ||
<references /> | <references /> | ||
Revision as of 17:44, 13 November 2011
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Papain
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Structure
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