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2j3n

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(New page: 200px<br /> <applet load="2j3n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j3n, resolution 2.80&Aring;" /> '''X-RAY STRUCTURE OF ...)
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==About this Structure==
==About this Structure==
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2J3N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD, NAP and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3N OCA]].
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2J3N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD, NAP and MPD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J3N OCA]].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Thioredoxin-disulfide reductase]]
[[Category: Becker, K.]]
[[Category: Becker, K.]]
[[Category: Fritz-Wolf, K.]]
[[Category: Fritz-Wolf, K.]]
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[[Category: selenocysteine]]
[[Category: selenocysteine]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:32:10 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:38:31 2007''

Revision as of 10:33, 30 October 2007

Image:2j3n.gif

2j3n, resolution 2.80Å

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X-RAY STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1

Overview

Human thioredoxin reductase (hTrxR) is a homodimeric flavoprotein, crucially involved in the regulation of cellular redox reactions, growth, and differentiation. The enzyme contains a selenocysteine residue at its, C-terminal active site that is essential for catalysis. This redox center, is located on a flexible arm, solvent-exposed and reactive towards, electrophilic inhibitors, thus representing a target for antitumor drug, development. During catalysis reducing equivalents are transferred from, the cofactor NADPH to FAD, then to the N-terminal active site cysteine, residues and from there to the flexible C-terminal part of the other, subunit to be finally delivered to a variety of second substrates at the, molecule's surface. Here we report the first crystal structure of hTrxR1, ... [(full description)]

About this Structure

2J3N is a [Single protein] structure of sequence from [Homo sapiens] with FAD, NAP and MPD as [ligands]. Active as [Thioredoxin-disulfide reductase], with EC number [1.8.1.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis., Fritz-Wolf K, Urig S, Becker K, J Mol Biol. 2007 Jun 29;370(1):116-27. Epub 2007 Apr 24. PMID:17512005

Page seeded by OCA on Tue Oct 30 12:38:31 2007

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