Sandbox 40
From Proteopedia
(Difference between revisions)
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<scene name='Sandbox_40/Lipase_qm/2'>polar and nonpolar residues</scene>. The polar residues in this scene are shown in a light blue shade, and the nonpolar are in a dark red. From this representation, it can be assumed that there is a similar quantity of polar residues as there are nonopolar. The tertiary stucture of the molecule is stabilized by 6 <scene name='Sandbox_40/Disulfide_bonds/1'>disulfide bonds</scene> and ionic interactions with a calcium ligand. Finally, the quaternary structure is completed by the adjoining of the two identical subunits. | <scene name='Sandbox_40/Lipase_qm/2'>polar and nonpolar residues</scene>. The polar residues in this scene are shown in a light blue shade, and the nonpolar are in a dark red. From this representation, it can be assumed that there is a similar quantity of polar residues as there are nonopolar. The tertiary stucture of the molecule is stabilized by 6 <scene name='Sandbox_40/Disulfide_bonds/1'>disulfide bonds</scene> and ionic interactions with a calcium ligand. Finally, the quaternary structure is completed by the adjoining of the two identical subunits. | ||
=The Calcium Ligand= | =The Calcium Ligand= | ||
| - | The <scene name='Sandbox_40/Lipase_ligand/1'>ligands of lipase</scene> are two calcium ions, one buried within each subunit. This scene shows the interactions between the calcium ion and the following residues: GLU187, ARG190, ASP192, and ASP195. In addition to interactions with these molecules, the calcium ion is also stabilized by the oxygens from two water molecules shown in pink. | + | The <scene name='Sandbox_40/Lipase_ligand/1'>ligands of lipase</scene> are two calcium ions, one buried within each subunit. This scene shows the interactions between the calcium ion in subunit A and the following residues from subunit A: GLU187, ARG190, ASP192, and ASP195. In addition to interactions with these molecules, the calcium ion is also stabilized by the oxygens from two water molecules shown in pink. |
=The Mechanism= | =The Mechanism= | ||
[[Image:Hydrolysis of trigly.png|200px|left|thumb| This is the reaction catalyzed by most lipases. Shown is a triglyceride being hydrolyzed by water, resulting in triglycerol and three fatty acids.]] | [[Image:Hydrolysis of trigly.png|200px|left|thumb| This is the reaction catalyzed by most lipases. Shown is a triglyceride being hydrolyzed by water, resulting in triglycerol and three fatty acids.]] | ||
<scene name='Sandbox_40/Active_site/1'>Active Site</scene> | <scene name='Sandbox_40/Active_site/1'>Active Site</scene> | ||
Revision as of 02:14, 14 November 2011
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
Horse Pancreatic Lipase
Introduction
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