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PhoP-PhoQ
From Proteopedia
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{{STRUCTURE_3bq8| PDB=3bq8 | SIZE=400| SCENE= |right|CAPTION=''E. coli'' Se-Met PhoQ complex with Ni+2 and acetic acid, [[3bq8]] }} | {{STRUCTURE_3bq8| PDB=3bq8 | SIZE=400| SCENE= |right|CAPTION=''E. coli'' Se-Met PhoQ complex with Ni+2 and acetic acid, [[3bq8]] }} | ||
| + | {{TOC limit|limit=2}} | ||
| - | '''PhoP-PhoQ''' is a two-component system which governs virulence and mediates the adptation to Mg+2-limiting conditions. PhoP is a response regulator and PhoQ is the inner membrane sensor. See details on PhoP in [[PhoP Regulatory Domain]]. | ||
| - | + | ===Introduction=== | |
| + | |||
| + | ---- | ||
| + | |||
| + | '''PhoP-PhoQ''' is a two-component system which governs virulence and mediates the adptation to Mg+2-limiting conditions. PhoP is a response regulator and PhoQ is the inner membrane sensor. See details on PhoP in [[PhoP Regulatory Domain]]. | ||
| - | < | + | ==PhoP==<StructureSection load='2pl1' size='500' side='right' caption='BeF activated PhoP domain of E. Coli (PDB entry [[2pl1]])' scene=''> |
| + | ===PhoP: A Response Regulator=== | ||
| + | ---- | ||
| + | PhoP's role in the phoP-phoQ two component phosphorelay system... | ||
| + | </StructureSection> | ||
== 3D Structures of PhoP-PhoQ== | == 3D Structures of PhoP-PhoQ== | ||
Revision as of 01:41, 15 November 2011
Introduction
PhoP-PhoQ is a two-component system which governs virulence and mediates the adptation to Mg+2-limiting conditions. PhoP is a response regulator and PhoQ is the inner membrane sensor. See details on PhoP in PhoP Regulatory Domain.
==PhoP==
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3D Structures of PhoP-PhoQ
PhoP
3r0j – MtPhoP – Mycobacterium tuberculosis
2pmu – MtPhoP DNA-binding domain
2pkx – EcPhoP regulatory domain (mutant) – Escherichia coli
2pl1 - EcPhoP regulatory domain (mutant) + BeF3
1mvo – PhoP N terminal – Bacillus subtilis
PhoQ
3cgy – StPhoQ catalytic domain + radicicol – Salmonella typhimurium
3cgz - StPhoQ catalytic domain
1yax - StPhoQ sensor domain (mutant)
3bq8 – EcPhoQ
3bqa – EcPhoQ (mutant)
1id0 – EcPhoQ kinase domain
