1e60
From Proteopedia
(New page: 200px<br /> <applet load="1e60" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e60, resolution 2.0Å" /> '''OXIDIZED DMSO REDUCT...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E60 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with SO4, PGD and 2MO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E60 OCA]]. | + | 1E60 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodobacter_capsulatus Rhodobacter capsulatus]] with SO4, PGD and 2MO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: MOA and MOC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E60 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: reductase]] | [[Category: reductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:39:30 2007'' |
Revision as of 10:34, 30 October 2007
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OXIDIZED DMSO REDUCTASE EXPOSED TO HEPES-STRUCTURE II BUFFER
Overview
Much is unknown concerning the role of thiolate ligands of molybdenum in, molybdopterin enzymes. It has been suggested that thiolate dissociation, from molybdenum is part of the catalytic mechanism of bis-molybdopterin, enzymes of the dimethyl sulfoxide reductase (DMSOR) family. For DMSOR from, Rhodobacter capsulatus, thiolate dissociation has therefore been, investigated crystallographically, by UV/visible spectroscopy, and by, enzyme assays. When crystallized from sodium citrate, all four thiolates, of DMSOR are within bonding distance of Mo, but after extended exposure to, Na(+)-Hepes, a pair of thiolates dissociates, a mixture of structures, being indicated after shorter exposures to this buffer. DMSOR is stable in, sodium citrate and other buffers but unstable aerobically although ... [(full description)]
About this Structure
1E60 is a [Single protein] structure of sequence from [Rhodobacter capsulatus] with SO4, PGD and 2MO as [ligands]. Structure known Active Sites: MOA and MOC. Full crystallographic information is available from [OCA].
Reference
Reversible dissociation of thiolate ligands from molybdenum in an enzyme of the dimethyl sulfoxide reductase family., Bray RC, Adams B, Smith AT, Bennett B, Bailey S, Biochemistry. 2000 Sep 19;39(37):11258-69. PMID:10985771
Page seeded by OCA on Tue Oct 30 12:39:30 2007
Categories: Rhodobacter capsulatus | Single protein | Adams, B. | Bailey, S. | Bennett, B. | Bray, R.C. | Smith, A.T. | 2MO | PGD | SO4 | Dmso | Molybdopterin | Oxidoreductase | Reductase
