1w33
From Proteopedia
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| - | [[Image:1w33.gif|left|200px]]<br /><applet load="1w33" size=" | + | [[Image:1w33.gif|left|200px]]<br /><applet load="1w33" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1w33, resolution 2.7Å" /> | caption="1w33, resolution 2.7Å" /> | ||
'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br /> | '''BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1W33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tick]] | [[Category: tick]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:18:43 2008'' |
Revision as of 08:18, 3 February 2008
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BBCRASP-1 FROM BORRELIA BURGDORFERI
Overview
Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.
About this Structure
1W33 is a Single protein structure of sequence from Borrelia burgdorferi with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564
Page seeded by OCA on Sun Feb 3 10:18:43 2008
Categories: Borrelia burgdorferi | Single protein | Brade, V. | Cordes, F.S. | Goodstadt, L. | Kirschfink, M. | Kraiczy, P. | Lea, S.M. | Ponting, C. | Roversi, P. | Simon, M.M. | Skerka, C. | Wallich, R. | Zipfel, P. | GOL | Complement regulator acquiring surface protein | Factor h binding | Lyme borreliosis | Membrane protein | Tick
