3sw2

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'''Unreleased structure'''
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[[Image:3sw2.jpg|left|200px]]
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The entry 3sw2 is ON HOLD until Paper Publication
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{{STRUCTURE_3sw2| PDB=3sw2 | SCENE= }}
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Authors: Klei, H.E.
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===X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide===
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Description: X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide
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{{ABSTRACT_PUBMED_22041058}}
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==About this Structure==
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[[3sw2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SW2 OCA].
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==Reference==
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<ref group="xtra">PMID:022041058</ref><references group="xtra"/>
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
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[[Category: Klei, H E.]]
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[[Category: Blood clotting]]
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[[Category: Blood coagulation factor]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Egf-like domain]]
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[[Category: Epidermal growth factor-like domain]]
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[[Category: Gamma-carboxyglutamic acid]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydroxylation]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]

Revision as of 12:15, 16 November 2011

Image:3sw2.jpg

Template:STRUCTURE 3sw2

X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide

Template:ABSTRACT PUBMED 22041058

About this Structure

3sw2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Shi Y, O'Connor SP, Sitkoff D, Zhang J, Shi M, Bisaha SN, Wang Y, Li C, Ruan Z, Michael Lawrence R, Klei HE, Kish K, Liu EC, Seiler SM, Schweizer L, Steinbacher TE, Schumacher WA, Robl JA, Macor JE, Atwal KS, Stein PD. Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg Med Chem Lett. 2011 Jun 28. PMID:22041058 doi:10.1016/j.bmcl.2011.06.098

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OCA

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