1wck
From Proteopedia
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| - | [[Image:1wck.gif|left|200px]]<br /><applet load="1wck" size=" | + | [[Image:1wck.gif|left|200px]]<br /><applet load="1wck" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1wck, resolution 1.36Å" /> | caption="1wck, resolution 1.36Å" /> | ||
'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.'''<br /> | '''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1WCK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with CAC as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Cac Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1WCK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with <scene name='pdbligand=CAC:'>CAC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Cac+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural protein]] | [[Category: structural protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:21:48 2008'' |
Revision as of 08:21, 3 February 2008
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.
Overview
The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can penetrate into the mammalian host by inhalation, causing a rapid, progression of the disease and a mostly fatal outcome. We have solved the, three-dimensional structure of the major surface protein BclA on B., anthracis spores. Surprisingly, the structure resembles C1q, the first, component of complement, despite there being no sequence homology., Although most assays for C1q-like activity, including binding to C1q, receptors, suggest that BclA does not mimic C1q, we show that BclA, as, well as C1q, interacts with components of the lung alveolar surfactant, layer. Thus, to better recognize and invade its hosts, this pathogenic, soil bacterium may have evolved a surface protein whose structure is, strikingly close to a mammalian protein.
About this Structure
1WCK is a Single protein structure of sequence from Bacillus anthracis with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins., Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A, J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:16249180
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