Beta-lactamase

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== 3D Structures of Beta-lactamase ==
== 3D Structures of Beta-lactamase ==
 +
 +
''Update November 2011''
===β-lactamase class A===
===β-lactamase class A===
-
[[3dtm]] - EcBlac A residues 24-286 (mutant) - ''Escherichia coli''<br />
+
[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]] - EcBlac A Tem-1 (mutant) - Escherichia coli<br />
-
[[3c7u]], [[3c7v]] – EcBlac A (mutant) + Protein Blip<br />
+
[[1btl]], [[1iys]], [[1xpb]], [[1zg4]] - EcBlac A Tem-1<br />
 +
[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
 +
[[1li0]] - EcBlac A Tem-32 (mutant) <br />
 +
[[1li9]] - EcBlac A Tem-34 (mutant) <br />
 +
[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
 +
[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]] - EcBlac A Toho-1 (mutant) <br />
 +
[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
 +
[[3c5a]] – EcBlac A Kpc-2<br />
 +
[[1ylj]], [[1ylp]], [[1ylt]], [[1ylw]], [[1yly]], [[1ylz]], [[1ym1]], [[1yms]], [[1ymx]], [[2p74]] – EcBlac A Ctx-M<br />
 +
[[3hre]] - EcBlac A Ctx-M (mutant) <br />
 +
[[1o7e]], [[1n4o]] – StmBlac A – Stenotrophonas maltophilia<br />
 +
[[1htz]] – KpBlac A Tem-52 – Klebsiella pneumoniae<br />
 +
[[1shv]] - KpBlac A Shv-1<br />
 +
[[1tdl]], [[2a3u]], [[3oph]], [[3opl]] - KpBlac A Shv-1 (mutant) <br />
 +
[[1n9b]] – KpBlac A Shv-2<br />
 +
[[2qpn]] – KpBlac A Ges-1<br />
 +
[[3ni9]] - PaBlac A Ges-2<br />
 +
[[1hzo]] – Blac A – Proteus vulgaris<br />
 +
[[1kge]], [[1kgf]], [[1kgg]], [[1ome]]– SaBlac A (mutant) - Staphylococcus aureus<br />
 +
[[3blm]] – SaBlac A<br />
 +
[[1mbl]], [[3ly3]] – BlBlac A (mutant) – Bacillus licheniformis<br />
 +
[[2blm]], [[3sh7]] – BlBlac A<br />
 +
[[2cc1]] – Blac A – Mycobacterium fortuitum<br />
 +
[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - Citrobacter sedlakii
 +
 
 +
===β-lactamase class A binary complex===
 +
 
[[1axb]] - EcBlac A (mutant) + transition state analog<br />
[[1axb]] - EcBlac A (mutant) + transition state analog<br />
-
[[1tem]] - EcBlac A (mutant) + penicillanic acid derivative<br />
+
[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]] - EcBlac A (mutant) + antibiotic<br />
-
[[1o7e]] – Blac – ''Stenotrophonas maltophilia''
+
[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
 +
1[[pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
 +
[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
 +
[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]] - EcBlac A Ctx-M + inhibitor<br />
 +
[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M (mutant) + antibiotic<br />
 +
[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
 +
[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]] - KpBlac A Shv-1 + inhibitor<br />
 +
[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
 +
[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
 +
[[1w7f ], [[3b3x]]- BlBlac A + inhibitor<br />
 +
[[3m2j]] - BlBlac A (mutant) + inhibitor<br />
 +
[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
 +
[[3ly4]], [[2m2k ]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
 +
[[2q9m]] - EncBlac A + inhibitor – Enterobacter cloacae<br />
 +
[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
 +
[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
 +
[[3p98]] – Blac Tem-72 + citrate – Morganella morganii
-
===β-lactamase class B===
+
===β-lactamase class A complex with β-lactamase inhibitor protein (Blip)===
-
[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]] – BcBlac B - ''Bacillus cereus''<br />
+
[[3c7u]], [[3c7v]], [[1jtg]], [[2b5r]] – EcBlac A (mutant) + Protein Blip<br />
-
[[3knr]], [[3kns]] - BcBlac C (mutant)
+
[[1jtd]], [[3gmw]] - EcBlac A + Protein Blip<br />
 +
[[1s0w]], [[1xxm]] - EcBlac A + Protein Blip (mutant) <br />
 +
[[2g2u]] - KpBlac A Shv-1 + Protein Blip<br />
 +
[[2g2w]], [[3n4i]] - KpBlac A Shv-1 (mutant) + Protein Blip<br />
 +
[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant) <br />
 +
[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip<br />
 +
[[3qhv]] - Blac A + Protein Blip – Bacillus anthracis
 +
 
 +
 
 +
===β-lactamase class B (Zn containing)===
 +
 
 +
[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]] – BcBlac B - Bacillus cereus<br />
 +
[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
 +
[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – Bacterioides fragilis<br />
 +
[[2znb]] - BfBlac B (Cd) <br />
 +
[[3znb]] – BfBlac B (Zn, Hg) <br />
 +
[[4znb]] - BfBlac B (mutant) <br />
 +
[[1k07]] – FgBlac B]] - Fluoribacter gormanii<br />
 +
[[1l9y]] - FgBlac B (mutant) <br />
 +
[[1ko2]], [[1ko3]] – PaBlac B Vim-2 - Pseudomonas aeruginosa<br />
 +
[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
 +
[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
 +
[[2fhx]] - PaBlac B Spm-1<br />
 +
[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – Serratia marcescens<br />
 +
[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – Thermus thermophilus<br />
 +
[[2zzi]] – TtBlac B (Fe) <br />
 +
[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B<br />
 +
[[2qin]], [[2qjs]] - StmBlac B (mutant) <br />
 +
[[2gmn]], [[3lvz]] – BjBlac B – Bradyrhizobium japonicum<br />
 +
[[2p4z]] – Blac B – Thermoanaerobacter tengcongensis<br />
 +
[[3f9o]] - AhBlac B – Aeromonas hydrophila<br />
 +
[[3fai]], [[1x8h]] - AhBlac B (mutant) <br />
 +
[[3l6n]] – Blac B – Chryseobacter indolegenes<br />
 +
[[3r2u]] – SaBlac B
 +
[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]] - KpBlac B Ndm-1<br />
 +
[[3srx]] - KpBlac B Ndm-1 (Cd) <br />
 +
[[3rkk]] - KpBlac B Ndm-1 (mutant) <br />
 +
[[3s0z]] - EcBlac B Ndm-1<br />
 +
[[2yz3]] – Blac Vim-2 – Pseudomonas putida<br />
 +
[[3sd9]] – SfBlac B]] - Serratia fonticola
 +
 
 +
===β-lactamase class B binary complex===
 +
 
 +
[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
 +
[[1jt1]] – FgBlac + captopril <br />
 +
[[1jje]], [[1jjt]], [[3lce]] - PaBlac B + inhibitor<br />
 +
[[1m2x]] – Blac B + captopril – Elizabethkingia meningoseptica<br />
 +
[[1vgn]] - SmBlac Imp-1+ inhibitor<br />
 +
[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
 +
[[2aio]] – StmBlac B + antibiotic<br />
 +
[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]] - StmBlac B + inhibitor<br />
 +
[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
 +
[[1x8g]], [[2gkl]] – AhBlac B + inhibitor<br />
 +
[[2qds]] – AhBlac B + captopril<br />
 +
[[3m8t]] – BjBlac B + inhibitor<br />
 +
[[3q6v]] – SfBlac B + glycerol <br />
 +
[[3q6x]] – KpBlac B Ndm-1+ antibiotic<br />
===β-lactamase class C===
===β-lactamase class C===
[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
-
[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid derivative<br />
+
[[1zkj]] – Blac C – Enterobacter aerogenes<br />
-
[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid derivative<br />
+
[[2qz6]] – Blac C – Pseudomonas fluorescens
 +
 
 +
===β-lactamase class C binary complex===
 +
 
 +
[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
 +
[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
-
[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor
+
[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor<br />
 +
[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
 +
[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
 +
[[1rgz]] - EncBlac C + antribiotic<br />
 +
[[1rgy]] - CfBlac C + antribiotic – Citrobacter freundii<br />
 +
[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
 +
[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
===β-lactamase class D===
===β-lactamase class D===
-
[[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]] – PaBlac D – ''Pseudomonas aeruginosa''<br />
+
[[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]], [[1ddk]], [[1e3u]], [[1e4d]], [[1h8z]] – PaBlac D <br />
-
[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]] - PaBlac D (mutant) <br />
+
[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]], [[2wgw]], [[2wki]] - PaBlac D (mutant) <br />
-
[[1k6r]] - PaBlac D + moxalactam<br />
+
[[1k56]], [[2k02]] - PaBlac Pse-2<br />
 +
[[1g68]], [[1k4f]] – PaBlac Pse-4<br />
 +
[[1g6a]] – PaBlac Pse-4 (mutant) <br />
 +
[[1ko2]] – PaBlac Vim-2<br />
 +
[[1k38]] – Blac D – Salmonella typhimurium<br />
 +
[[1m6k]] – EcBlac D<br />
 +
[[3hbr]] – KpBlac D Oxa-48<br />
 +
[[3if6]] - KpBlac D Oxa-46
 +
 
 +
===β-lactamase class D binary complex===
 +
 
 +
[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br />
 +
[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
[[1k6s]] - PaBlac D + phenylboronic acid<br />
[[1k6s]] - PaBlac D + phenylboronic acid<br />
-
[[1k54]] - PaBlac D + penicillanic acid derivative<br />
+
[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
 +
[[3isg]] – EcBlac D + inhibitor<br />
 +
[[3pae]], [[3pag]] - AbBlac D (mutant) + inhibitor<br />
 +
 
 +
===AmpC β-lactamase===
 +
 
 +
[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br />
 +
[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]] - EcBlac (mutant)
 +
[[1fcn ]]– EcBlac (mutant) + substrate<br />
 +
[[1fco]], [[1i5q]], [[1kvl]] - EcBlac (mutant) + antibiotic<br />
 +
[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]] - EcBlac + antibiotic<br />
 +
[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]] - EcBlac + boronic acid inhibitor<br />
 +
[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
 +
[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]] - EcBlac + inhibitor<br />
 +
[[1o07]] - EcBlac (mutant) + inhibitor<br />
 +
[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
 +
 
 +
===Non-classified β-lactamase===
 +
 
 +
[[1bsg]] – Blac – Streptomyces albus<br />
 +
[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
 +
[[1gce]], [[1xx2]] - EncBlac <br />
 +
[[1dy6]] – SmBlac Sme-1<br />
 +
[[1fr1]], [[1fr6]] – CfBlac <br />
 +
[[1i2s]] – BlBlac<br />
 +
[[2gdn]] – MtBlac – Mycobacterium tuberculosis<br />
 +
[[2jc7]], [[3g4p]] – AbBlac – Acinetobacter baumannii<br />
 +
[[3byd]] – Blac – Klebsiella oxytoca<br />
 +
[[3i7j]] – Blac – Mycobacterium bovis<br />
 +
[[3lez]] – Blac – ''Oceanobacter iheyensis''<br />
 +
[[3p09]] – Blac – ''Francisella tularensis''<br />
 +
[[4blm]] - BlBlac
 +
 
 +
===Non-classified β-lactamase binary complex===
 +
 
 +
[[1ghm]], [[1ghp]], [[1pio]] - SaBlac (mutant) + antibiotic<br />
 +
[[1blc]], [[1blh]]– SaBlac + inhibitor<br />
 +
[[1bls ]]– EncBlac + phosphonate derivative <br />
 +
[[1bul]] - EncBlac + penicillin derivative<br />
 +
[[1ga0]] - EncBlac + inhibitor<br />
 +
[[1i2w]] – BlBlac + cifoxitin<br />
 +
[[3cg5]] – MtBlac + antibiotic<br />
 +
[[3n8s]], [[3ny4]] - MtBlac (mutant) + antibiotic<br />
 +
[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
 +
[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
 +
 
 +
 
-
[[1bsg]] – Blac – ''Streptomyces albus''
 

Revision as of 10:13, 22 November 2011

Image:3bm6.png
Crystal Structure of Beta-lactamase, 3bm6

Template:STRUCTURE 3bm6

Beta-lactamase (Blac) are enzymes which make bacteria resitant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.


Contents



3D Structures of Beta-lactamase

Update November 2011

β-lactamase class A

3dtm, 1bza, 1ck3, 1esu, 1jwp, 1lhy, 1li0, 1m40, 1zg6, 2v1z, 2v20, 3cmz - EcBlac A Tem-1 (mutant) - Escherichia coli
1btl, 1iys, 1xpb, 1zg4 - EcBlac A Tem-1
1lhy - EcBlac A Tem-30 (mutant)
1li0 - EcBlac A Tem-32 (mutant)
1li9 - EcBlac A Tem-34 (mutant)
1yt4 - EcBlac A Tem-76 (mutant)
1we4, 2xr0, 2zq7, 2zq8, 2zq9, 2zqa, 2zqc, 2zqd - EcBlac A Toho-1 (mutant)
2xqz, 2wyx - EcBlac A Toho-1 (mutant) – Neutron
3c5a – EcBlac A Kpc-2
1ylj, 1ylp, 1ylt, 1ylw, 1yly, 1ylz, 1ym1, 1yms, 1ymx, 2p74 – EcBlac A Ctx-M
3hre - EcBlac A Ctx-M (mutant)
1o7e, 1n4o – StmBlac A – Stenotrophonas maltophilia
1htz – KpBlac A Tem-52 – Klebsiella pneumoniae
1shv - KpBlac A Shv-1
1tdl, 2a3u, 3oph, 3opl - KpBlac A Shv-1 (mutant)
1n9b – KpBlac A Shv-2
2qpn – KpBlac A Ges-1
3ni9 - PaBlac A Ges-2
1hzo – Blac A – Proteus vulgaris
1kge, 1kgf, 1kgg, 1ome– SaBlac A (mutant) - Staphylococcus aureus
3blm – SaBlac A
1mbl, 3ly3 – BlBlac A (mutant) – Bacillus licheniformis
2blm, 3sh7 – BlBlac A
2cc1 – Blac A – Mycobacterium fortuitum
3bfd, 3bfe – CsBlac A Sed-1 (mutant) - Citrobacter sedlakii

β-lactamase class A binary complex

1axb - EcBlac A (mutant) + transition state analog
1tem, 1bt5, 1fqg, 1iyo, 1iyp, 1iyq, 1jvj - EcBlac A (mutant) + antibiotic
1nxy, 1ny0, 1nym, 1nyy - EcBlac A (mutant) + boronic acid inhibitor
1pzo, 1pzp - EcBlac A Tem-1 (mutant) + inhibitor
1erm, 1ero, 1erq – EcBlac A Tem-1 + boronic acid inhibitor
3g2y, 3g2z, 3g30, 3g31, 3g32, 3g34, 3g35 - EcBlac A Ctx-M + inhibitor
3hlw, 3huo, 3hvf - EcBlac A Ctx-M (mutant) + antibiotic
1jwv, 1jwz - EcBlac A Tem-1 (mutant) + boronic acid inhibitor
1ong, 1q2p, 1vm1, 2h5s, 2zd8, 3d4f, 3mke, 3mkf, 3mxr, 3mxs - KpBlac A Shv-1 + inhibitor
1rcj, 1tdg, 2a49, 2h0t, 2h0y, 2h10 - KpBlac A Shv-1 (mutant) + inhibitor
3opp, 3opr- KpBlac A Shv-1 (mutant) + antibiotic
[[1w7f ], 3b3x- BlBlac A + inhibitor
3m2j - BlBlac A (mutant) + inhibitor
2wk0, 2x71– BlBlac A + antibiotic
3ly4, 2m2k , 3sh8, 3sh9 - BlBlac A (mutant) + antibiotic
2q9m - EncBlac A + inhibitor – Enterobacter cloacae
3bfc, 3bff, 3bfg – CsBlac A Sed-1 (mutant) + inhibitor
3nia - PaBlac A Ges-2 + inhibitor
3p98 – Blac Tem-72 + citrate – Morganella morganii

β-lactamase class A complex with β-lactamase inhibitor protein (Blip)

3c7u, 3c7v, 1jtg, 2b5r – EcBlac A (mutant) + Protein Blip
1jtd, 3gmw - EcBlac A + Protein Blip
1s0w, 1xxm - EcBlac A + Protein Blip (mutant)
2g2u - KpBlac A Shv-1 + Protein Blip
2g2w, 3n4i - KpBlac A Shv-1 (mutant) + Protein Blip
3c4o, 3c4p - KpBlac A Shv-1 + Protein Blip (mutant)
3e2k, 3e2l - KpBlac A Kpc-2 (mutant) + Protein Blip
3qhv - Blac A + Protein Blip – Bacillus anthracis


β-lactamase class B (Zn containing)

3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15, 1bc2, 1bvt, 1mqo, 2bc2, 3bc2, 1bmc – BcBlac B - Bacillus cereus
3knr, 3kns, 1dxk, 2bfk, 2bfl, 2bfz, 2bg2, 2bg6, 2bg7, 2bg8, 2bga, 2nxa, 2nyp, 2nze, 2nzf, 2uyx - BcBlac B (mutant)
1a7t, 1znb, 2bmi – BfBlac B – Bacterioides fragilis
2znb - BfBlac B (Cd)
3znb – BfBlac B (Zn, Hg)
4znb - BfBlac B (mutant)
1k07 – FgBlac B]] - Fluoribacter gormanii
1l9y - FgBlac B (mutant)
1ko2, 1ko3 – PaBlac B Vim-2 - Pseudomonas aeruginosa
2whg, 2wrs - PaBlac B Vim-4
2y87, 2y8a, 2y8b - PaBlac B Vim-7
2fhx - PaBlac B Spm-1
1wuo, 1wup - SmBlac Imp-1 (mutant) – Serratia marcescens
2dkf, 2zo4, 2zwr – TtBlac B – Thermus thermophilus
2zzi – TtBlac B (Fe)
2fm6, 2fu6, 2fu7, 2h6a – StmMlac B
2qin, 2qjs - StmBlac B (mutant)
2gmn, 3lvz – BjBlac B – Bradyrhizobium japonicum
2p4z – Blac B – Thermoanaerobacter tengcongensis
3f9o - AhBlac B – Aeromonas hydrophila
3fai, 1x8h - AhBlac B (mutant)
3l6n – Blac B – Chryseobacter indolegenes
3r2u – SaBlac B 3rkj, 3sbl, 3sfp, 3spu, 3zr9 - KpBlac B Ndm-1
3srx - KpBlac B Ndm-1 (Cd)
3rkk - KpBlac B Ndm-1 (mutant)
3s0z - EcBlac B Ndm-1
2yz3 – Blac Vim-2 – Pseudomonas putida
3sd9 – SfBlac B]] - Serratia fonticola

β-lactamase class B binary complex

1a8t, 1hlk, 1kr3 - BfBlac B + inhibitor
1jt1 – FgBlac + captopril
1jje, 1jjt, 3lce - PaBlac B + inhibitor
1m2x – Blac B + captopril – Elizabethkingia meningoseptica
1vgn - SmBlac Imp-1+ inhibitor
2doo - SmBlac Imp-1+ fluorescent agent
2aio – StmBlac B + antibiotic
2fu8, 2fu9, 2gfj, 2gfk, 2hb9, 2qdt - StmBlac B + inhibitor
3iof, 1x8i, 3iog– AhBlac B (mutant) + inhibitor
1x8g, 2gkl – AhBlac B + inhibitor
2qds – AhBlac B + captopril
3m8t – BjBlac B + inhibitor
3q6v – SfBlac B + glycerol
3q6x – KpBlac B Ndm-1+ antibiotic

β-lactamase class C

3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)
1zkj – Blac C – Enterobacter aerogenes
2qz6 – Blac C – Pseudomonas fluorescens

β-lactamase class C binary complex

3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid inhibitor
3ixb, 3ixg - EcBlac C (mutant) + boronic acid inhibitor
3ixh - EcBlac C (mutant) + cefotaxime
3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb - EcBlac C + inhibitor
1onh, 1q2q, 1y54 - EncBlac C + inhibitor
1s6r - EncBlac C+ boronic acid inhibitor
1rgz - EncBlac C + antribiotic
1rgy - CfBlac C + antribiotic – Citrobacter freundii
1zc2, 2zc7 – KpBlac C + inhibitor
2wzx, 2wzz – PaBlac C + inhibitor

β-lactamase class D

2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof, 1ddk, 1e3u, 1e4d, 1h8z – PaBlac D
2hp5, 2hp6, 2hp9, 2hpb, 2wgw, 2wki - PaBlac D (mutant)
1k56, 2k02 - PaBlac Pse-2
1g68, 1k4f – PaBlac Pse-4
1g6a – PaBlac Pse-4 (mutant)
1ko2 – PaBlac Vim-2
1k38 – Blac D – Salmonella typhimurium
1m6k – EcBlac D
3hbr – KpBlac D Oxa-48
3if6 - KpBlac D Oxa-46

β-lactamase class D binary complex

1k6r, 1k54 - PaBlac D + antibiotic
2wgi, 2wkh - PaBlac D (mutant) + antibiotic
1k6s - PaBlac D + phenylboronic acid
1dd6, 1h5x, 1h8y, 2wgv - PaBlac D + inhibitor
3isg – EcBlac D + inhibitor
3pae, 3pag - AbBlac D (mutant) + inhibitor

AmpC β-lactamase

1ke4, 2bls, 2zj9, 3bls – EcBlac
1l0d, 1l0e, 1l0f, 1l0g - EcBlac (mutant) 1fcn – EcBlac (mutant) + substrate
1fco, 1i5q, 1kvl - EcBlac (mutant) + antibiotic
1iel, 1fcm, 1iem, 1kvm, 1ll5, 1ll9, 1llb - EcBlac + antibiotic
1fsw, 1fsy, 1kds, 1kdw, 1ke0, 1ke3, 1mxo, 1my8 - EcBlac + boronic acid inhibitor
1pi4, 1pi5, 2ffy - EcBlac (mutant) + boronic acid inhibitor
1l2s, 1xgi, 1xgj, 2hdq, 2hdr, 2hds, 2hdu, 2p9v, 2pu2, 2pu4, 2r9w, 2r9x, 2rcx - EcBlac + inhibitor
1o07 - EcBlac (mutant) + inhibitor
3s1y, 3s22 - PaBlac (mutant) + inhibitor

Non-classified β-lactamase

1bsg – Blac – Streptomyces albus
1alq, 1blp, 1dja, 1djb, 1djc, 1ghi – SaBlac (mutant)
1gce, 1xx2 - EncBlac
1dy6 – SmBlac Sme-1
1fr1, 1fr6 – CfBlac
1i2s – BlBlac
2gdn – MtBlac – Mycobacterium tuberculosis
2jc7, 3g4p – AbBlac – Acinetobacter baumannii
3byd – Blac – Klebsiella oxytoca
3i7j – Blac – Mycobacterium bovis
3lez – Blac – Oceanobacter iheyensis
3p09 – Blac – Francisella tularensis
4blm - BlBlac 

===Non-classified β-lactamase binary complex===

1ghm, 1ghp, 1pio - SaBlac (mutant) + antibiotic
1blc, 1blh– SaBlac + inhibitor
1bls – EncBlac + phosphonate derivative
1bul - EncBlac + penicillin derivative
1ga0 - EncBlac + inhibitor
1i2w – BlBlac + cifoxitin
3cg5 – MtBlac + antibiotic
3n8s, 3ny4 - MtBlac (mutant) + antibiotic
3dwz, 3iqa, 3m6b, 3m6h – MtBlac + inhibitor
3fv7, 3fyz, 3fzc, 3mbz – AbBlac + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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