2bgd
From Proteopedia
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| - | [[Image:2bgd.gif|left|200px]]<br /><applet load="2bgd" size=" | + | [[Image:2bgd.gif|left|200px]]<br /><applet load="2bgd" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bgd, resolution 2.40Å" /> | caption="2bgd, resolution 2.40Å" /> | ||
'''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''<br /> | '''STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BGD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL, PO4, NA and T1D as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Po4 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BGD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=T1D:'>T1D</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Known structural/functional Site: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:23:44 2008'' |
Revision as of 08:23, 3 February 2008
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STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Contents |
Overview
Using structure-based design, a new class of inhibitors of protein, tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the, 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
Disease
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]
About this Structure
2BGD is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Protein-tyrosine-phosphatase, with EC number 3.1.3.48 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Sun Feb 3 10:23:44 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Black, E. | Breed, J. | Breeze, A.L. | Embrey, K. | Garcia, R. | Gero, T.W. | Godfrey, L. | Kenny, P.W. | Minshull, C.A. | Morley, A.D. | Pannifer, A.D. | Read, J. | Rees, A. | Russell, D.J. | Toader, D. | Tucker, J. | CL | NA | PO4 | T1D | 1 | 1-dioxide template | 2 | 5-thiadiazolidin-3-one-1 | Hydrolase | Protein tyrosine phosphatase
