2biw
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2biw.gif|left|200px]]<br /><applet load="2biw" size=" | + | [[Image:2biw.gif|left|200px]]<br /><applet load="2biw" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2biw, resolution 2.39Å" /> | caption="2biw, resolution 2.39Å" /> | ||
'''CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME'''<br /> | '''CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.] with FE and 3ON as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2BIW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb66_1.html Carotenoid Oxygenase]]. Known structural/functional Site: <scene name='pdbsite=AC1:Fe Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=3ON:'>3ON</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2BIW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb66_1.html Carotenoid Oxygenase]]. Known structural/functional Site: <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIW OCA]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 28: | ||
[[Category: retinal formation]] | [[Category: retinal formation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:24:40 2008'' |
Revision as of 08:24, 3 February 2008
|
CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME
Overview
Enzymes that produce retinal and related apocarotenoids constitute a, sequence- and thus structure-related family, a member of which was, analyzed by x-ray diffraction. This member is an oxygenase and contains an, Fe2+-4-His arrangement at the axis of a seven-bladed beta-propeller chain, fold covered by a dome formed by six large loops. The Fe2+ is accessible, through a long nonpolar tunnel that holds a carotenoid derivative in one, of the crystals. On binding, three consecutive double bonds of this, carotenoid changed from a straight all-trans to a cranked cis-trans-cis, conformation. The remaining trans bond is located at the dioxygen-ligated, Fe2+ and cleaved by oxygen.
About this Structure
2BIW is a Single protein structure of sequence from Synechocystis sp. with and as ligands. The following page contains interesting information on the relation of 2BIW with [Carotenoid Oxygenase]. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The structure of a retinal-forming carotenoid oxygenase., Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE, Science. 2005 Apr 8;308(5719):267-9. PMID:15821095
Page seeded by OCA on Sun Feb 3 10:24:40 2008
