2bkf
From Proteopedia
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| - | [[Image:2bkf.gif|left|200px]]<br /><applet load="2bkf" size=" | + | [[Image:2bkf.gif|left|200px]]<br /><applet load="2bkf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bkf, resolution 1.56Å" /> | caption="2bkf, resolution 1.56Å" /> | ||
'''STRUCTURE OF THE PB1 DOMAIN OF NBR1'''<br /> | '''STRUCTURE OF THE PB1 DOMAIN OF NBR1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BKF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BKF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BKF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:25:06 2008'' |
Revision as of 08:25, 3 February 2008
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STRUCTURE OF THE PB1 DOMAIN OF NBR1
Overview
The scaffold protein NBR1 is involved in signal transmission downstream of, the serine/protein kinase from the giant muscle protein titin. Its, N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating, protein-protein interactions with both titin kinase and with another, scaffold protein, p62. We have determined the crystal structure of the PB1, domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with, two negatively charged residue clusters. We provide a structural, perspective on the involvement of NBR1 in the titin kinase signalling, pathway.
About this Structure
2BKF is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the PB1 domain of NBR1., Muller S, Kursula I, Zou P, Wilmanns M, FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PMID:16376336
Page seeded by OCA on Sun Feb 3 10:25:06 2008
Categories: Homo sapiens | Single protein | Kursula, I. | Mueller, S. | Wilmanns, M. | GOL | Interaction domain | Nbr1 | Pb1 domain | Polymorphism | Zinc-finger
