2blf
From Proteopedia
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| - | [[Image:2blf.gif|left|200px]]<br /><applet load="2blf" size=" | + | [[Image:2blf.gif|left|200px]]<br /><applet load="2blf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2blf, resolution 1.80Å" /> | caption="2blf, resolution 1.80Å" /> | ||
'''SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA'''<br /> | '''SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BLF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Starkeya_novella Starkeya novella] with SO4, MSS and HEC as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BLF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Starkeya_novella Starkeya novella] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MSS:'>MSS</scene> and <scene name='pdbligand=HEC:'>HEC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sulfite oxidase]] | [[Category: sulfite oxidase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:25:28 2008'' |
Revision as of 08:25, 3 February 2008
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SULFITE DEHYDROGENASE FROM STARKEYA NOVELLA
Overview
Sulfite-oxidizing molybdoenzymes convert the highly reactive and therefore, toxic sulfite to sulfate and have been identified in insects, animals, plants, and bacteria. Although the well studied enzymes from higher, animals serve to detoxify sulfite that arises from the catabolism of, sulfur-containing amino acids, the bacterial enzymes have a central role, in converting sulfite formed during dissimilatory oxidation of reduced, sulfur compounds. Here we describe the structure of the Starkeya novella, sulfite dehydrogenase, a heterodimeric complex of the catalytic, molybdopterin subunit and a c-type cytochrome subunit, that reveals the, molecular mechanism of intramolecular electron transfer in, sulfite-oxidizing enzymes. The close approach of the two redox centers in, the protein complex (Mo-Fe distance 16.6 A) allows for rapid electron, transfer via tunnelling or aided by the protein environment. The high, resolution structure of the complex has allowed the identification of, potential through-bond pathways for electron transfer including a direct, link via Arg-55A and/or an aromatic-mediated pathway. A potential site of, electron transfer to an external acceptor cytochrome c was also identified, on the SorB subunit on the opposite side to the interaction with the, catalytic SorA subunit.
About this Structure
2BLF is a Protein complex structure of sequences from Starkeya novella with , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Molecular basis of intramolecular electron transfer in sulfite-oxidizing enzymes is revealed by high resolution structure of a heterodimeric complex of the catalytic molybdopterin subunit and a c-type cytochrome subunit., Kappler U, Bailey S, J Biol Chem. 2005 Jul 1;280(26):24999-5007. Epub 2005 Apr 29. PMID:15863498
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Categories: Protein complex | Starkeya novella | Bailey, S. | Kappler, U. | HEC | MSS | SO4 | C-type cytochrome | Electron transport | Heme | Molybdopterin | Oxidoreductase | Sulfite oxidase
