FK506 binding protein
From Proteopedia
(New page: {{STRUCTURE_1fkd| PDB=1fkd | SIZE=400| SCENE= |right|CAPTION=Human FKBP12 complex with immunosuppressant, 1fkd }} ''FK506 binding protein'' (FKBP) is a prolyl isomerase related to t...) |
|||
| Line 6: | Line 6: | ||
== 3D Structures of FKBP == | == 3D Structures of FKBP == | ||
| + | |||
| + | ===FKPB3=== | ||
| + | |||
| + | [[3kz7]] – hFKBP FK506-binding domain + immunosuppressant - human | ||
| + | |||
| + | ===FKPB4=== | ||
| + | |||
| + | [[1q1c]] – hFKBP | ||
| + | [[1n1a]] – hFKBP N terminal | ||
| + | [[1p5q]] - hFKBP C terminal | ||
| + | [[1qz2]] – hFKBP + Hsp90 peptide | ||
| + | |||
| + | ===FKBP5=== | ||
| + | |||
| + | [[3o5d]], [[3o5e]], [[3o5f]] – hFKBP | ||
| + | [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK506-binding domain | ||
| + | [[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3p5q]] - hFKBP FK506-binding domain (mutant) | ||
| + | [[3o5r]] - hFKBP FK506-binding domain (mutant) + immunosuppressant | ||
| + | |||
| + | ===FKBP8=== | ||
| + | |||
| + | [[2f2d]], [[3ey6]], [[2awg]] - hFKBP FK506-binding domain | ||
| + | [[2d9f]] – hFKBP – NMR | ||
| + | [[2jwx]] - hFKBP N terminal - NMR | ||
| + | |||
| + | ===FKBP12=== | ||
| + | |||
| + | [[1eym]] – hFKBP (mutant) | ||
| + | [[1fkk]] – hFKBP | ||
| + | [[2gaq]], [[2pnu]]– hFKBP]] - NMR | ||
| + | [[1fkd]], [[1fkj]], [[2fke]], [[1qpf]], [[1qpl]] – hFKBP + immunosuppressant | ||
| + | [[1j4h]], [[1j4i]] – hFKBP + inhibitor | ||
| + | [[1b6c]] – hFKBP + TGF-B superfamily receptor I | ||
| + | [[3fap]] – hFKBP + FKBP12-rapamycin associated protein | ||
| + | [[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant | ||
| + | [[1tco]] - FKBP + Ser/Thr phosphatase B2 + immunosuppressant]] - bovine | ||
| + | [[1yat]] – FKBP + antagonist – yeast | ||
| + | |||
| + | ===FKBP26=== | ||
| + | |||
| + | [[3pr9]], [[3pra]], [[3prb]], [[3prd]] – FKBP – ''Methanocaldococcus jannaschii'' | ||
| + | |||
| + | ===FKBP59=== | ||
| + | |||
| + | [[1rot]], [[1rou]] – FKBP N terminal – NMR – rabbit | ||
| + | |||
| + | [[2kr7]] – FKBP SlyD – NMR]] - ''Helicobacter pylori'' | ||
| + | [[2lgo]] – FKBP – NMR –'' Giardia lamblia'' | ||
| + | |||
| + | |||
| + | |||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:29, 24 November 2011
FK506 binding protein (FKBP) is a prolyl isomerase related to the cyclophilins. FKBP is a folding chaperone for proteins containing prolines. FKBP12 binds the immunosuppressor tacrolimus (FK506) which is used against organ rejection.
Contents |
3D Structures of FKBP
FKPB3
3kz7 – hFKBP FK506-binding domain + immunosuppressant - human
FKPB4
1q1c – hFKBP 1n1a – hFKBP N terminal 1p5q - hFKBP C terminal 1qz2 – hFKBP + Hsp90 peptide
FKBP5
3o5d, 3o5e, 3o5f – hFKBP 3o5g, 3o5i, 3o5j, 3o5k - hFKBP FK506-binding domain 3o5l, 3o5m, 3o5o, 3o5p, 3p5q - hFKBP FK506-binding domain (mutant) 3o5r - hFKBP FK506-binding domain (mutant) + immunosuppressant
FKBP8
2f2d, 3ey6, 2awg - hFKBP FK506-binding domain 2d9f – hFKBP – NMR 2jwx - hFKBP N terminal - NMR
FKBP12
1eym – hFKBP (mutant) 1fkk – hFKBP 2gaq, 2pnu– hFKBP]] - NMR 1fkd, 1fkj, 2fke, 1qpf, 1qpl – hFKBP + immunosuppressant 1j4h, 1j4i – hFKBP + inhibitor 1b6c – hFKBP + TGF-B superfamily receptor I 3fap – hFKBP + FKBP12-rapamycin associated protein 4fap - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant 1tco - FKBP + Ser/Thr phosphatase B2 + immunosuppressant]] - bovine 1yat – FKBP + antagonist – yeast
FKBP26
3pr9, 3pra, 3prb, 3prd – FKBP – Methanocaldococcus jannaschii
FKBP59
1rot, 1rou – FKBP N terminal – NMR – rabbit
2kr7 – FKBP SlyD – NMR]] - Helicobacter pylori 2lgo – FKBP – NMR – Giardia lamblia
