FK506 binding protein
From Proteopedia
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===FKPB4=== | ===FKPB4=== | ||
| - | [[1q1c]] – hFKBP | + | [[1q1c]] – hFKBP <br /> |
| - | [[1n1a]] – hFKBP N terminal | + | [[1n1a]] – hFKBP N terminal<br /> |
| - | [[1p5q]] - hFKBP C terminal | + | [[1p5q]] - hFKBP C terminal<br /> |
[[1qz2]] – hFKBP + Hsp90 peptide | [[1qz2]] – hFKBP + Hsp90 peptide | ||
===FKBP5=== | ===FKBP5=== | ||
| - | [[3o5d]], [[3o5e]], [[3o5f]] – hFKBP | + | [[3o5d]], [[3o5e]], [[3o5f]] – hFKBP<br /> |
| - | [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK506-binding domain | + | [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK506-binding domain<br /> |
| - | [[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3p5q]] - hFKBP FK506-binding domain (mutant) | + | [[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3p5q]] - hFKBP FK506-binding domain (mutant)<br /> |
[[3o5r]] - hFKBP FK506-binding domain (mutant) + immunosuppressant | [[3o5r]] - hFKBP FK506-binding domain (mutant) + immunosuppressant | ||
===FKBP8=== | ===FKBP8=== | ||
| - | [[2f2d]], [[3ey6]], [[2awg]] - hFKBP FK506-binding domain | + | [[2f2d]], [[3ey6]], [[2awg]] - hFKBP FK506-binding domain<br /> |
| - | [[2d9f]] – hFKBP – NMR | + | [[2d9f]] – hFKBP – NMR<br /> |
[[2jwx]] - hFKBP N terminal - NMR | [[2jwx]] - hFKBP N terminal - NMR | ||
===FKBP12=== | ===FKBP12=== | ||
| - | [[1eym]] – hFKBP (mutant) | + | [[1eym]] – hFKBP (mutant) <br /> |
| - | [[1fkk]] – hFKBP | + | [[1fkk]] – hFKBP<br /> |
| - | [[2gaq]], [[2pnu]]– hFKBP]] - NMR | + | [[2gaq]], [[2pnu]]– hFKBP]] - NMR<br /> |
| - | [[1fkd]], [[1fkj]], [[2fke]], [[1qpf]], [[1qpl]] – hFKBP + immunosuppressant | + | [[1fkd]], [[1fkj]], [[2fke]], [[1qpf]], [[1qpl]] – hFKBP + immunosuppressant<br /> |
| - | [[1j4h]], [[1j4i]] – hFKBP + inhibitor | + | [[1j4h]], [[1j4i]] – hFKBP + inhibitor<br /> |
| - | [[1b6c]] – hFKBP + TGF-B superfamily receptor I | + | [[1b6c]] – hFKBP + TGF-B superfamily receptor I<br /> |
| - | [[3fap]] – hFKBP + FKBP12-rapamycin associated protein | + | [[3fap]] – hFKBP + FKBP12-rapamycin associated protein<br /> |
| - | [[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant | + | [[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br /> |
| - | [[1tco]] - FKBP + Ser/Thr phosphatase B2 + immunosuppressant | + | [[1tco]] - FKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br /> |
[[1yat]] – FKBP + antagonist – yeast | [[1yat]] – FKBP + antagonist – yeast | ||
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[[1rot]], [[1rou]] – FKBP N terminal – NMR – rabbit | [[1rot]], [[1rou]] – FKBP N terminal – NMR – rabbit | ||
| - | [[2kr7]] – FKBP SlyD – NMR]] - ''Helicobacter pylori'' | + | [[2kr7]] – FKBP SlyD – NMR]] - ''Helicobacter pylori''<br /> |
[[2lgo]] – FKBP – NMR –'' Giardia lamblia'' | [[2lgo]] – FKBP – NMR –'' Giardia lamblia'' | ||
Revision as of 10:31, 24 November 2011
FK506 binding protein (FKBP) is a prolyl isomerase related to the cyclophilins. FKBP is a folding chaperone for proteins containing prolines. FKBP12 binds the immunosuppressor tacrolimus (FK506) which is used against organ rejection.
Contents |
3D Structures of FKBP
FKPB3
3kz7 – hFKBP FK506-binding domain + immunosuppressant - human
FKPB4
1q1c – hFKBP
1n1a – hFKBP N terminal
1p5q - hFKBP C terminal
1qz2 – hFKBP + Hsp90 peptide
FKBP5
3o5d, 3o5e, 3o5f – hFKBP
3o5g, 3o5i, 3o5j, 3o5k - hFKBP FK506-binding domain
3o5l, 3o5m, 3o5o, 3o5p, 3p5q - hFKBP FK506-binding domain (mutant)
3o5r - hFKBP FK506-binding domain (mutant) + immunosuppressant
FKBP8
2f2d, 3ey6, 2awg - hFKBP FK506-binding domain
2d9f – hFKBP – NMR
2jwx - hFKBP N terminal - NMR
FKBP12
1eym – hFKBP (mutant)
1fkk – hFKBP
2gaq, 2pnu– hFKBP]] - NMR
1fkd, 1fkj, 2fke, 1qpf, 1qpl – hFKBP + immunosuppressant
1j4h, 1j4i – hFKBP + inhibitor
1b6c – hFKBP + TGF-B superfamily receptor I
3fap – hFKBP + FKBP12-rapamycin associated protein
4fap - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant
1tco - FKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine
1yat – FKBP + antagonist – yeast
FKBP26
3pr9, 3pra, 3prb, 3prd – FKBP – Methanocaldococcus jannaschii
FKBP59
1rot, 1rou – FKBP N terminal – NMR – rabbit
2kr7 – FKBP SlyD – NMR]] - Helicobacter pylori
2lgo – FKBP – NMR – Giardia lamblia
