User:User:Marcia Ivonne Peña Paz
From Proteopedia
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Brain and muscle Arnt like 1. Also known as MOP3 | Brain and muscle Arnt like 1. Also known as MOP3 | ||
| - | + | BMAL1 is a basic helix-loop-helix transcription factor. | |
| - | It | + | It is part of the transcriptional/translational feed back loop of the circadian timing system. |
| - | + | ||
| - | + | It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. The heterodimer formed in the cytoplasm migrates to the nucleus where it binds to E-box promoter of target genes, acting as the positive feedback. They promote the transcription of Per and Cry genes, whose proteins form the negative feed back loop, they heterodimerize and repress CLOCK-BMAL1 complex activity. | |
CLOCK-BMAL1 complex regulate clock-controlled genes, modulating food intake, hormonal synthesis, body temperature and metabolism. | CLOCK-BMAL1 complex regulate clock-controlled genes, modulating food intake, hormonal synthesis, body temperature and metabolism. | ||
It modulates the expression of the genes ''RevErbα'' (nuclear repressor), ''Dbp'' (D site albumin promoter)''Cry 1/2'', ''Per 1/2/3'', ''Dbp'', ''Rorα'', ''Pparα'', ''Namt'', ''Ccg'', ''MyoD'', ''CKIε''. | It modulates the expression of the genes ''RevErbα'' (nuclear repressor), ''Dbp'' (D site albumin promoter)''Cry 1/2'', ''Per 1/2/3'', ''Dbp'', ''Rorα'', ''Pparα'', ''Namt'', ''Ccg'', ''MyoD'', ''CKIε''. | ||
Revision as of 13:01, 28 November 2011
BMAL_1
Brain and muscle Arnt like 1. Also known as MOP3
BMAL1 is a basic helix-loop-helix transcription factor.
It is part of the transcriptional/translational feed back loop of the circadian timing system.
It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. The heterodimer formed in the cytoplasm migrates to the nucleus where it binds to E-box promoter of target genes, acting as the positive feedback. They promote the transcription of Per and Cry genes, whose proteins form the negative feed back loop, they heterodimerize and repress CLOCK-BMAL1 complex activity.
CLOCK-BMAL1 complex regulate clock-controlled genes, modulating food intake, hormonal synthesis, body temperature and metabolism. It modulates the expression of the genes RevErbα (nuclear repressor), Dbp (D site albumin promoter)Cry 1/2, Per 1/2/3, Dbp, Rorα, Pparα, Namt, Ccg, MyoD, CKIε.
