1h42

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(New page: 200px<br /> <applet load="1h42" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h42, resolution 2.15&Aring;" /> '''FERREDOXIN:NADP+ RE...)
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==About this Structure==
==About this Structure==
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1H42 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]] with SO4 and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.1.2 1.18.1.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H42 OCA]].
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1H42 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]] with SO4 and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Ferredoxin--NADP(+)_reductase Ferredoxin--NADP(+) reductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.1.2 1.18.1.2]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H42 OCA]].
==Reference==
==Reference==
Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity., Tejero J, Martinez-Julvez M, Mayoral T, Luquita A, Sanz-Aparicio J, Hermoso JA, Hurley JK, Tollin G, Gomez-Moreno C, Medina M, J Biol Chem. 2003 Dec 5;278(49):49203-14. Epub 2003 Sep 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14500716 14500716]
Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity., Tejero J, Martinez-Julvez M, Mayoral T, Luquita A, Sanz-Aparicio J, Hermoso JA, Hurley JK, Tollin G, Gomez-Moreno C, Medina M, J Biol Chem. 2003 Dec 5;278(49):49203-14. Epub 2003 Sep 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14500716 14500716]
[[Category: Anabaena sp.]]
[[Category: Anabaena sp.]]
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[[Category: Ferredoxin--NADP(+) reductase]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Gomez-Moreno, C.]]
[[Category: Gomez-Moreno, C.]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:38:09 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:42:27 2007''

Revision as of 10:37, 30 October 2007


1h42, resolution 2.15Å

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FERREDOXIN:NADP+ REDUCTASE MUTANT WITH THR 155 REPLACED BY GLY, ALA 160 REPLACED BY THR AND LEU 263 REPLACED BY PRO (T155G-A160T-L263P)

Overview

Previous studies indicated that the determinants of coenzyme specificity, in ferredoxin-NADP+ reductase (FNR) from Anabaena are situated in the, 2'-phosphate (2'-P) NADP+ binding region, and also suggested that other, regions must undergo structural rearrangements of the protein backbone, during coenzyme binding. Among the residues involved in such specificity, could be those located in regions where interaction with the pyrophosphate, group of the coenzyme takes place, namely loops 155-160 and 261-268 in, Anabaena FNR. In order to learn more about the coenzyme specificity, determinants, and to better define the structural basis of coenzyme, binding, mutations in the pyrophosphate and 2'-P binding regions of FNR, have been introduced. Modification of the pyrophosphate binding region, ... [(full description)]

About this Structure

1H42 is a [Single protein] structure of sequence from [Anabaena sp.] with SO4 and FAD as [ligands]. Active as [Ferredoxin--NADP(+) reductase], with EC number [1.18.1.2]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Involvement of the pyrophosphate and the 2'-phosphate binding regions of ferredoxin-NADP+ reductase in coenzyme specificity., Tejero J, Martinez-Julvez M, Mayoral T, Luquita A, Sanz-Aparicio J, Hermoso JA, Hurley JK, Tollin G, Gomez-Moreno C, Medina M, J Biol Chem. 2003 Dec 5;278(49):49203-14. Epub 2003 Sep 18. PMID:14500716

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