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From Proteopedia
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This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer. | This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer. | ||
== Aromatase Inhibitors == | == Aromatase Inhibitors == | ||
| - | Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. | + | Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. <ref> "Aromatase Inhibitors" [http://www.breastcancer.org/treatment/hormonal/aromatase_inhibitors/] <ref/> |
There are three Aromatase Inhibitors that are often used in the treatment of breast cancer: | There are three Aromatase Inhibitors that are often used in the treatment of breast cancer: | ||
*Arimidex (Anastrozole) | *Arimidex (Anastrozole) | ||
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Contents |
Aromatase
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Introduction
Aromatase belongs to the cytochrome p450 family. During aromatization reactions, Aromatase forms an electron-transfer complex with its partner, NADPH-cytochrome p450 reductase. Aromatase is an enzyme that aids in the biosynthesis of estrogens. The aromatase enzyme can be found in many tissues in the body such as the brain, placenta, adipose tissue, blood vessels, gonads, endometrium, skin, and bone.
Function
This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer.
Aromatase Inhibitors
Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. [1]
- Aromatase Excess Syndrome
Research shows a rare disorder caused by excessive aromatase activity that can cause familial gynecomastia and feminization of both sexes. This can be inherited by an autosomal dominant manner, affected females and males differently. Females with this disorder showed signs of isosexual precocity and/or macromastia. Males showed characteristics of heterosexual precocity and/or gynecomastia. [2]
