Talk:Guanine riboswitch
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Erin Elizabeth Sherman (Talk | contribs)
(New page: ==Background== Human dopamine D3 receptor is a protein that encoded by the dopamine receptor gene (DRD3).<ref>Le Coniat M, Sokoloff P, Hillion J, Martres MP, Giros B, Pilon C, Schwartz JC,...)
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Revision as of 23:51, 29 November 2011
Background
Human dopamine D3 receptor is a protein that encoded by the dopamine receptor gene (DRD3).[1] "Chromosomal localization of the human D3 dopamine receptor gene". Hum Genet 87 (5): 618–20. The DRD3 gene codes for the D3 dopamine receptor that inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is located in the brain, suggesting that the D3 receptor plays a role in cognitive and emotional functions.[2]
Ligands
Ligands that are associated with dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide (ETQ on PDB) and maltose (MAL on PDB). ETQ binds to dopamine D3 receptor by Asp 110A and Phe346A. MAL binds by Asp 1020A, Glu 1022A, Glu1011A, and Leu1032A.[3]
