2bsy
From Proteopedia
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| - | [[Image:2bsy.gif|left|200px]]<br /><applet load="2bsy" size=" | + | [[Image:2bsy.gif|left|200px]]<br /><applet load="2bsy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bsy, resolution 1.50Å" /> | caption="2bsy, resolution 1.50Å" /> | ||
'''EPSTEIN BARR VIRUS DUTPASE'''<br /> | '''EPSTEIN BARR VIRUS DUTPASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with SO4 and UMP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=UMP:'>UMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] Known structural/functional Site: <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BSY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:27:30 2008'' |
Revision as of 08:27, 3 February 2008
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EPSTEIN BARR VIRUS DUTPASE
Overview
Deoxyuridine 5'-triphosphate pyrophosphatases (dUTPases) are ubiquitous, enzymes cleaving dUTP into dUMP and pyrophosphate. They occur as, monomeric, dimeric, or trimeric molecules. The trimeric and monomeric, enzymes both contain the same five characteristic sequence motifs but in a, different order, whereas the dimeric enzymes are not homologous. Monomeric, dUTPases only occur in herpesviruses, such as Epstein-Barr virus (EBV)., Here, we describe the crystal structures of EBV dUTPase in complex with, the product dUMP and a substrate analog alpha,beta-imino-dUTP. The, molecule consists of three domains forming one active site that has a, structure extremely similar to one of the three active sites of trimeric, dUTPases. The three domains functionally correspond to the subunits of the, trimeric form. Domains I and II have the dUTPase fold, but they differ, considerably in the regions that are not involved in the formation of the, unique active site, whereas domain III has only little secondary, structure.
About this Structure
2BSY is a Single protein structure of sequence from Human herpesvirus 4 with and as ligands. Active as dUTP diphosphatase, with EC number 3.6.1.23 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases., Tarbouriech N, Buisson M, Seigneurin JM, Cusack S, Burmeister WP, Structure. 2005 Sep;13(9):1299-310. PMID:16154087
Page seeded by OCA on Sun Feb 3 10:27:30 2008
Categories: Human herpesvirus 4 | Single protein | DUTP diphosphatase | Buisson, M. | Burmeister, W.P. | Cusack, S. | SPINE, Structural.Proteomics.in.Europe. | Seigneurin, J.M. | Tarbouriech, N. | SO4 | UMP | Dutpase | Hydrolase | Monomer | Nucleotide metabolism | Spine | Structural genomics | Structural proteomics in europe
