Group:MUZIC:DARP
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Narendra Kumar Verma (Talk | contribs)
(New page: __FORCETOC__ '''Introduction''' Diabetes related ankyrin repeat protein DARP (Ankrd23) and its two close homologs Ankrd2/Arpp and Ankrd1/CARP correspond to a conserved gene family of mus...)
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Revision as of 14:44, 30 November 2011
Introduction
Diabetes related ankyrin repeat protein DARP (Ankrd23) and its two close homologs Ankrd2/Arpp and Ankrd1/CARP correspond to a conserved gene family of muscle ankyrin repeat proteins (MARPs) [1]. DARP is expressed in both heart and skeletal muscle (in addition to brown fat) and was identified by its upregulation in Type 2 diabetes and insulin-resistant animals, suggesting a potential role in energy metabolism. [2]
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Structure
DARP contains putative nuclear localization signals, four tandem ankyrin-like repeats, potential coiled-coil dimerization motif within its unique aminoterminal domain that mediates the formation of homodimers. [3] DARP interacts with a tyrosine-rich binding motif between Ig80 and Ig81 of titin and with myopalladin. [1]
Gene Function
DARP knock out muscle fibers were less stiff, tended to have longer resting sarcomere lengths, and expressed a longer isoform of titin than their wild-type counterparts, indicating that this protein may play a role in the passive mechanical behavior of muscle. [4] DARP expression is altered by a change of energy supply and energy metabolic condition, induced by excess fatty acid treatment in vitro and fasting in vivo. [2] The expression of DARP is induced during recovery following starvation. In cultured fetal rat cardiac myocytes, passive stretch induced differential distribution patterns of DARP: staining for DARP was increased in the nucleus, at the I-band region of myofibrils and also at intercalated discs. [1] Differently from its homolog genes, DARP is not upregulated after ECs.[5]
