2byo
From Proteopedia
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| - | [[Image:2byo.gif|left|200px]]<br /><applet load="2byo" size=" | + | [[Image:2byo.gif|left|200px]]<br /><applet load="2byo" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2byo, resolution 2.15Å" /> | caption="2byo, resolution 2.15Å" /> | ||
'''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LIPOPROTEIN LPPX (RV2945C)'''<br /> | '''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LIPOPROTEIN LPPX (RV2945C)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BYO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with ZN, ACT, OAA, MLT, HXA and LNL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mlt Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2BYO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=OAA:'>OAA</scene>, <scene name='pdbligand=MLT:'>MLT</scene>, <scene name='pdbligand=HXA:'>HXA</scene> and <scene name='pdbligand=LNL:'>LNL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mlt+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: palmitate]] | [[Category: palmitate]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:29:26 2008'' |
Revision as of 08:29, 3 February 2008
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LIPOPROTEIN LPPX (RV2945C)
Overview
Cell envelope lipids play an important role in the pathogenicity of, mycobacteria, but the mechanisms by which they are transported to the, outer membrane of these prokaryotes are largely unknown. Here, we provide, evidence that LppX is a lipoprotein required for the translocation of, complex lipids, the phthiocerol dimycocerosates (DIM), to the outer, membrane of Mycobacterium tuberculosis. Abolition of DIM transport, following disruption of the lppX gene is accompanied by an important, attenuation of the virulence of the tubercle bacillus. The crystal, structure of LppX unveils an U-shaped beta-half-barrel dominated by a, large hydrophobic cavity suitable to accommodate a single DIM molecule., LppX shares a similar fold with the periplasmic molecular chaperone LolA, and the outer membrane lipoprotein LolB, which are involved in the, localization of lipoproteins to the outer membrane of Gram-negative, bacteria. Based on the structure and although an indirect participation of, LppX in DIM transport cannot yet be ruled out, we propose LppX to be the, first characterized member of a family of structurally related, lipoproteins that carry lipophilic molecules across the mycobacterial cell, envelope.
About this Structure
2BYO is a Single protein structure of sequence from Mycobacterium tuberculosis with , , , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis., Sulzenbacher G, Canaan S, Bordat Y, Neyrolles O, Stadthagen G, Roig-Zamboni V, Rauzier J, Maurin D, Laval F, Daffe M, Cambillau C, Gicquel B, Bourne Y, Jackson M, EMBO J. 2006 Apr 5;25(7):1436-44. Epub 2006 Mar 16. PMID:16541102
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Categories: Mycobacterium tuberculosis | Single protein | Bourne, Y. | Canaan, S. | Gicquel, B. | Maurin, D. | Roig-Zamboni, V. | Sulzenbacher, G. | ACT | HXA | LNL | MLT | OAA | ZN | Lipid transport | Lipoprotein | Membrane | Palmitate
