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Histone methyltransferase
From Proteopedia
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== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
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| + | ''Updated December 2011'' | ||
[[1nw3]] – hHMT DOT1L – human | [[1nw3]] – hHMT DOT1L – human | ||
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[[2j8a]] – KHMT SET1 RRM domain – yeast | [[2j8a]] – KHMT SET1 RRM domain – yeast | ||
| - | [[3s8s]] – hKHMT SETD1A RRM domain | + | [[3s8s]] – hKHMT SETD1A RRM domain<br /> |
| - | + | [[1h3i]] - hKHMT SET7/9 residues 52-344<br /> | |
| + | [[1o9s]] - hKHMT SET7/9 residues 52-344 + H3 peptide<br /> | ||
| + | [[2bqz]] - hKHMT SET7 residues 192-352 + H4 peptide<br /> | ||
| + | [[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | ||
| + | [[2rfi]], [[3hna]] - hKHMT H3K9 catalytic domain + H3 peptide<br /> | ||
| + | [[3n71]] - hKHMT Smyd1<br /> | ||
[[3rib]] – hKHMT Smyd2 + SAH | [[3rib]] – hKHMT Smyd2 + SAH | ||
Revision as of 10:19, 1 December 2011
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
3D Structures of histone methyltransferase
Updated December 2011
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
1h3i - hKHMT SET7/9 residues 52-344
1o9s - hKHMT SET7/9 residues 52-344 + H3 peptide
2bqz - hKHMT SET7 residues 192-352 + H4 peptide
2o8j - hKHMT H3K9 residues 913-1193
2rfi, 3hna - hKHMT H3K9 catalytic domain + H3 peptide
3n71 - hKHMT Smyd1
3rib – hKHMT Smyd2 + SAH
3s7b - hKHMT Smyd2 + SAM + inhibitor
3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide
3s7j, 3tg4 - hKHMT Smyd2 + SAM
