Sandbox Reserved 387

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<Structure load='3RJ1' size='400' frame='true' align='left' caption='Mediator' scene='Insert optional scene name here' />
<Structure load='3RJ1' size='400' frame='true' align='left' caption='Mediator' scene='Insert optional scene name here' />
'''
'''
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== Mediator Background==
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== Mediator ==
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The Mediators connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 21725323 </ref>.
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The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription <ref>PMID: 21725323 </ref> (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression <ref>PMID: 21725323 </ref>. Mediator is in the form of three main modules, which are the tail, arm, and head.
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== Mediator Structure ==
== Mediator Structure ==
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The mediator is organized into three modules, the tail, the arm, and the head. The
<scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene>
<scene name='Sandbox_Reserved_387/Head_module/1'>head module</scene>

Revision as of 23:06, 2 December 2011

This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing. For an example of a student Proteopedia page, please see Photosystem II, Tetanospasmin, or Guanine riboswitch.


Mediator

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Contents

Mediator

The Mediator, found in the yeast S. cerevisiae, connects repressors and activators bound to regulatory DNA with RNA polymerase II because the mediator is an important regulator of eukaryotic transcription [1] (Pol II). Also, mediator is currently being studied because of its ability and role to regulate gene expression [2]. Mediator is in the form of three main modules, which are the tail, arm, and head.



Mediator Structure

The mediator is organized into three modules, the tail, the arm, and the head. The


Regulation Mechanism

[3]


References

  1. ↑ Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162. PMID:21725323 doi:10.1038/nature10162
  2. ↑ Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y. Architecture of the Mediator head module. Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162. PMID:21725323 doi:10.1038/nature10162
  3. ↑ Serganov A, Yuan YR, Pikovskaya O, Polonskaia A, Malinina L, Phan AT, Hobartner C, Micura R, Breaker RR, Patel DJ. Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem Biol. 2004 Dec;11(12):1729-41. PMID:15610857 doi:S1074-5521(04)00343-6
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