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(New page: {{STRUCTURE_1xtc| PDB=1xtc | SIZE=500| SCENE=Cholera_toxin/Cv/1 |right|CAPTION=Cholera toxin 1xtc }} Cholera toxin (CTX) from the bacterium ''Vibrio cholerae'' is an oligomeric...)
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Cholera toxin 1xtc

Structural annotation:
Resources:	CATH : 1Xtca00, 1Xtcc00, 1Xtcd00, 1Xtce00, 1Xtcf00, 1Xtcg00, 1Xtch00 InterPro : Ipr000886, Ipr001144, Ipr008992, Ipr001835 Pfam : PF01375, PF01376 SCOP : d1xtc.1, d1xtcd_, d1xtce_, d1xtcf_, d1xtcg_, d1xtch_ UniProt : P01555, P01556

Functional annotation:
Cellular component:	extracellular region membrane
Biological process:	pathogenesis
Molecular function:	NAD+-diphthamide ADP-ribosyltransferase activity transferase activity, transferring glycosyl groups transferase activity catalytic activity

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Cholera toxin (CTX) from the bacterium Vibrio cholerae is an oligomeric complex of an enzymatic subunit (chain A) and 5 copies of chain B which bind to the cell surface. The enzymatic subunit has a globular domain (CTA1) and a long helical domain (CTA2). Once the CTX binds to the cell surface, it is internalized, and its CTA1 domain binds to ADP-ribosylation factor 6 (Arf6) enabling its catalytic activity. The images at the left and at the right correspond to the crystal structure of cholera toxin (1xtc).

1 3D Structures of Cholera toxin

3D Structures of Cholera toxin

Updated November 2011

CTX

1xtc - CTX

CTX A subunit

2a5d, 2a5g – CTX A subunit+hArf6+GTP – human
2a5f - CTX A subunit+hArf6+GTP+NAD
1s5b, 1s5c, 1s5d, 1s5e, 1s5f - CTX A subunit (mutant)

CTX B subunits

1fgb - CTX B subunits
1g8z , 1chp, 1chq - CTX B subunits (mutant)
1rcv, 1rd9, 1rdp, 1rf2, 1pzi, 1pzj, 1pzk, 1efi, 1eef, 1djr, 1eei – CTX B subunits+ galactoside derivatives
1llr, 1jqy, 1jr0, 1fd7, 1md2 - CTX B subunits+BMSC derivatives
1eef - CTX B subunits+PEPG
3chb, 2chb - CTX B subunits+pentasaccharide
1ct1 - CTX B subunits (mutant)+pentasaccharide
3efx – CTX B/heat-labile enterotoxin B chain
1tet – CTX peptide 3+FAB light and heavy chains - mouse