User:Khaja Muneeruddin/Sandbox 1
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(New page: One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. Human Tr...)
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Revision as of 16:02, 8 December 2011
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Human Transferrin (hTf) is a 80 KDa bilobal glycoprotein. The N-lobe and C-lobe of hTf binds to one ferric ion each to keep ferric ion in solution or transport to iron requiring cells.
Diferric HTf binds to human transferrin receptor (hTfR) expressed on the surface of iron requiring cells. Upon binding, Fe2hTf-hTfR is internalized in the cell by endocytosis. The acidic condition of endosome causes the release of ferric ions in cells and the ApohTf-HTfR is recycled back to cell surface to release ApohTf in plasma where it can bind to ferric ions again.
