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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
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[[
Bold textImage:intactModelLargeText.jpg|frame|Dihydrofolate Reductase]] One of the
CBI Molecules being studied in the
University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the
Molecular Playground. DHFR is awesome and I rule.
=== Ligand-binding domain === The spinning protein () ) is the ligand binding domain of the aspartate receptor with the aspartate ligand bound (LKT). Molecular Playground banner: A bacterial chemotaxis receptor protein used by bacteria to "smell" their environment.
=== Chemotaxis adaptor protein CheW === CheW is a chemotaxis adaptor protein, and part of the tertiary complex formed by the chemotaxis receptor, histidine kinase protein CheA, and CheW. As an adaptor protein, CheW mediates the interaction between the chemotaxis receptor and CheA, and is necessary for the formation of kinase active complexes. CheW has been found to bind to the P5 domain of CheA through crystallographic studies. At right, CheW is shown with suppression mutants (blue)that have been measured to decrease receptor binding and chemotaxis (SMJ).
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