Proliferating Cell Nuclear Antigen
From Proteopedia
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[[Image:1rwz.png|left|200px|thumb|Crystal Structure of Proliferating Cell Nuclear Antigen [[1rwz]]]] | [[Image:1rwz.png|left|200px|thumb|Crystal Structure of Proliferating Cell Nuclear Antigen [[1rwz]]]] | ||
| - | {{STRUCTURE_1rwz| PDB=1rwz | SIZE= | + | {{STRUCTURE_1rwz| PDB=1rwz | SIZE=400| SCENE=Proliferating_Cell_Nuclear_Antigen/Cv/1 |right|CAPTION=Proliferating Cell Nuclear Antigen [[1rwz]] }} |
[[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, ''i.e.'' the crystal structure of Proliferating Cell Nuclear Antigen from ''Archaeglobus fulgidus'' ([[1rwz]]). | [[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, ''i.e.'' the crystal structure of Proliferating Cell Nuclear Antigen from ''Archaeglobus fulgidus'' ([[1rwz]]). | ||
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== 3D Structures of Proliferating Cell Nuclear Antigen == | == 3D Structures of Proliferating Cell Nuclear Antigen == | ||
| - | ''Update | + | ''Update December 2011'' |
===Unliganded PCNA=== | ===Unliganded PCNA=== | ||
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[[1vym]], [[1w60]] – hPCNA - human<br /> | [[1vym]], [[1w60]] – hPCNA - human<br /> | ||
[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br /> | [[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br /> | ||
| - | [[2hii]], [[2hik]], [[2ixi]] - SsPCNA A + PCNA B + PCNA C<br /> | + | [[2hii]], [[2hik]], [[2ixi]], [[2ix2]] - SsPCNA A + PCNA B + PCNA C<br /> |
[[2nti]] - SsPCNA A + PCNA B (mutant) + PCNA C<br /> | [[2nti]] - SsPCNA A + PCNA B (mutant) + PCNA C<br /> | ||
[[2ijx]] - SsPCNA A<br /> | [[2ijx]] - SsPCNA A<br /> | ||
| - | [[1iz4]], [[1iz5]] – PfPCNA (mutant) - ''Pyrococcus furiosus''<br /> | + | [[1iz4]], [[1iz5]], [[1ge8]] – PfPCNA (mutant) - ''Pyrococcus furiosus''<br /> |
[[3hi8]], [[3ifv]] - PCNA - ''Haloferax volcanii''<br /> | [[3hi8]], [[3ifv]] - PCNA - ''Haloferax volcanii''<br /> | ||
| - | [[3aix]], [[3aiz]] - | + | [[3aix]], [[3aiz]] - StPCNA B + PCNA C – ''Sulfolobus tokodaii''<br /> |
| + | [[1ud9]] - StPCNA<br /> | ||
[[3p91]] – PCNA – ''Entamoeba histoytiica'' | [[3p91]] – PCNA – ''Entamoeba histoytiica'' | ||
Revision as of 09:57, 14 December 2011
Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, i.e. the crystal structure of Proliferating Cell Nuclear Antigen from Archaeglobus fulgidus (1rwz).
Contents |
3D Structures of Proliferating Cell Nuclear Antigen
Update December 2011
Unliganded PCNA
1rwz – AfPCNA - Archaeglobus fulgidus
3lx1 - TkPCNA1 - Thermococcus kodakarensis
3lx2 - TkPCNA2
3lox, 1plq, 1plr – yPCNA - yeast
3f1x, 3gpm, 3gpn, 3f1w - yPCNA (mutant)
3l0x - yPCNA N fragment + C fragment
3gpe - yPCNA N fragment + SUMO-C fragment
1vym, 1w60 – hPCNA - human
2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus
2hii, 2hik, 2ixi, 2ix2 - SsPCNA A + PCNA B + PCNA C
2nti - SsPCNA A + PCNA B (mutant) + PCNA C
2ijx - SsPCNA A
1iz4, 1iz5, 1ge8 – PfPCNA (mutant) - Pyrococcus furiosus
3hi8, 3ifv - PCNA - Haloferax volcanii
3aix, 3aiz - StPCNA B + PCNA C – Sulfolobus tokodaii
1ud9 - StPCNA
3p91 – PCNA – Entamoeba histoytiica
PCNA + Dpo
2zvk – hPCNA + hDpo ε
2zvl – hPCNA + hDpo κ
2zvm – hPCNA + hDpo τ
3fds – SsPCNA B + PCNA C + SsDpo IV
3a2f - PfPCNA + Dpo
PCNA complexes
1vyj, 1u76, 1u7b – hPCNA + peptide
1axc - hPCNA + P21/WAF1 C-terminat
1ul1 - hPCNA + Flap exonuclease-1
3p87 - hPCNA + RNase H2 subunit B (mutant)
3p83 - AfPCNA + RNase H2
1rxm – AfPCNA + Flap exonuclease-1 peptide
1rxz - AfPCNA + Flap structure-specific endonuclease
3l0w, 3l10 - yPCNA + monoubiquinated PCNA
1sxj – yPCNA + replication factor C
2od8 - yPCNA + DNA ligase fragment
3k4x - yPCNA + DNA
2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease
1isq - PfPCNA (mutant) + replication factor C large subunit
2zvw - PCNA + cyclin-dependent kinase inhibitor 1 - Arabidopsis thaliana
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Lukáš Cakl, Joel L. Sussman
