3skc

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Revision as of 10:47, 14 December 2011

Template:STRUCTURE 3skc

Human B-Raf Kinase in Complex with an Amide Linked Pyrazolopyridine Inhibitor

Template:ABSTRACT PUBMED 21802293

About this Structure

3skc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Wenglowsky S, Ahrendt KA, Buckmelter AJ, Feng B, Gloor SL, Gradl S, Grina J, Hansen JD, Laird ER, Lunghofer P, Mathieu S, Moreno D, Newhouse B, Ren L, Risom T, Rudolph J, Seo J, Sturgis HL, Voegtli WC, Wen Z. Pyrazolopyridine inhibitors of B-Raf(V600E). Part 2: Structure-activity relationships. Bioorg Med Chem Lett. 2011 Jul 2. PMID:21802293 doi:10.1016/j.bmcl.2011.06.097