2ccq
From Proteopedia
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| - | [[Image:2ccq.gif|left|200px]]<br /><applet load="2ccq" size=" | + | [[Image:2ccq.gif|left|200px]]<br /><applet load="2ccq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ccq, resolution 1.6Å" /> | caption="2ccq, resolution 1.6Å" /> | ||
'''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''<br /> | '''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CCQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2CCQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:33:58 2008'' |
Revision as of 08:33, 3 February 2008
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THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.
Overview
The AAA ATPase p97 is a ubiquitin-selective molecular machine involved in, multiple cellular processes, including protein degradation through the, ubiquitin-proteasome system and homotypic membrane fusion. Specific p97, functions are mediated by a variety of cofactors, among them peptide, N-glycanase, an enzyme that removes glycans from misfolded glycoproteins., Here we report the three-dimensional structure of the aminoterminal PUB, domain of human peptide N-glycanase. We demonstrate that the PUB domain is, a novel p97 binding module interacting with the D1 and/or D2 ATPase, domains of p97 and identify an evolutionary conserved surface patch, required for p97 binding. Furthermore, we show that the PUB and UBX, domains do not bind to p97 in a mutually exclusive manner. Our results, suggest that PUB domain-containing proteins constitute a widespread family, of diverse p97 cofactors.
About this Structure
2CCQ is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The PUB domain functions as a p97 binding module in human peptide N-glycanase., Allen MD, Buchberger A, Bycroft M, J Biol Chem. 2006 Sep 1;281(35):25502-8. Epub 2006 Jun 28. PMID:16807242
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