2chd
From Proteopedia
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| - | [[Image:2chd.gif|left|200px]]<br /><applet load="2chd" size=" | + | [[Image:2chd.gif|left|200px]]<br /><applet load="2chd" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2chd, resolution 1.92Å" /> | caption="2chd, resolution 1.92Å" /> | ||
'''CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A'''<br /> | '''CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2CHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:35:19 2008'' |
Revision as of 08:35, 3 February 2008
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CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A
Overview
Rabphilin-3A is a neuronal protein containing a C2-domain tandem. To date, only the structure of the C2B domain has been solved. The crystal, structure of the Ca2+-free C2A domain has been solved by molecular, replacement and refined to 1.92 A resolution. It adopts the classical, C2-domain fold consisting of an eight-stranded antiparallel beta-sandwich, with type I topology. In agreement with its Ca2+-dependent negatively, charged membrane-binding properties, this C2 domain contains all the, conserved acidic residues responsible for calcium binding. However, the, replacement of a conserved aspartic acid residue by glutamic acid allows, formation of an additional strong hydrogen bond, resulting in increased, rigidity of calcium-binding loop 1. The electrostatic surface of the C2A, domain consists of a large positively charged belt surrounded by two, negatively charged patches located at both tips of the domain. In, comparison, the structurally very similar C2A domain of synaptotagmin I, has a highly acidic electrostatic surface, suggesting completely unrelated, functions for these two C2A domains.
About this Structure
2CHD is a Single protein structure of sequence from Rattus norvegicus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the C2A domain of rabphilin-3A., Biadene M, Montaville P, Sheldrick GM, Becker S, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):793-9. Epub 2006, Jun 20. PMID:16790935
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