2cji
From Proteopedia
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| - | [[Image:2cji.gif|left|200px]]<br /><applet load="2cji" size=" | + | [[Image:2cji.gif|left|200px]]<br /><applet load="2cji" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2cji, resolution 2.10Å" /> | caption="2cji, resolution 2.10Å" /> | ||
'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2CJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and GSK as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Known structural/functional Site: <scene name='pdbsite=AC1:Gsk Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2CJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=GSK:'>GSK</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Known structural/functional Site: <scene name='pdbsite=AC1:Gsk+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:36:08 2008'' |
Revision as of 08:36, 3 February 2008
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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX
Contents |
Overview
A series of novel, non-basic, 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa), inhibitors, incorporating an alanylamide P4 group, was designed and, synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl, derivative 24 was shown to be a potent, selective fXa inhibitor with good, anticoagulant activity. Moreover, 24 possessed highly encouraging rat and, dog pharmacokinetic profiles with excellent oral bioavailabilities in both, species.
Disease
Known disease associated with this structure: Factor X deficiency OMIM:[227600]
About this Structure
2CJI is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Coagulation factor Xa, with EC number 3.4.21.6 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors., Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell C, Patel C, Patel VK, Senger S, Shah GP, Weston HE, Whitworth C, Young RJ, Bioorg Med Chem Lett. 2006 Jul 15;16(14):3784-8. Epub 2006 May 11. PMID:16697194
Page seeded by OCA on Sun Feb 3 10:36:08 2008
Categories: Coagulation factor Xa | Homo sapiens | Single protein | Campbell, M. | Chan, C. | Convery, M.A. | Hamblin, J.N. | Kelly, H.A. | King, N.P. | Mason, A.M. | Mitchell, C. | Patel, V.K. | Senger, S. | Shah, G.P. | Watson, N.S. | Weston, H.E. | Whitworth, C. | Young, R.J. | CA | GSK | Blood coagulation | Calcium | Egf-like domain | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase | Hydroxylation | Polymorphism | Protease | Serine protease | Zymogen
