User:Karan Hingorani/sandbox 1
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
Dihydrofolate Reductase (DHFR) is a crucial metabolic enzyme whose function is to reduce Dihydrofolate to Tetrahydrofolate, which can then be incorporated into the synthesis of Purines and amino acids. DHFR is classified as an oxidoreductase, which uses NADP+ as the electron acceptor (EC: 1.5.1.3). It is ubiquitously found and is now a popular target for anticancer drugs and antibiotics. | Dihydrofolate Reductase (DHFR) is a crucial metabolic enzyme whose function is to reduce Dihydrofolate to Tetrahydrofolate, which can then be incorporated into the synthesis of Purines and amino acids. DHFR is classified as an oxidoreductase, which uses NADP+ as the electron acceptor (EC: 1.5.1.3). It is ubiquitously found and is now a popular target for anticancer drugs and antibiotics. | ||
| - | <scene name='User:Karan_Hingorani/sandbox_1/Apo_dhfr/1'>Apo-DHFR</scene> | + | <scene name='User:Karan_Hingorani/sandbox_1/Apo_dhfr/1'>Apo-DHFR</scene> free of any of its ligands is displayed here. |
Revision as of 16:20, 14 December 2011
Contents |
Introduction
Dihydrofolate Reductase (DHFR) is a crucial metabolic enzyme whose function is to reduce Dihydrofolate to Tetrahydrofolate, which can then be incorporated into the synthesis of Purines and amino acids. DHFR is classified as an oxidoreductase, which uses NADP+ as the electron acceptor (EC: 1.5.1.3). It is ubiquitously found and is now a popular target for anticancer drugs and antibiotics. free of any of its ligands is displayed here.
Functions
DHFR binds everything and is super awesome
Catalysis
Test
|
Drug Target
metho and trimetho [1].
Templates used on this page:
PDB structures
2cbr - hCRABP I – human
1cbr - CRABP I + retinoic acid – mouse
