Sandbox 210

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[[Image:1h4l.jpg|left|200px]]
[[Image:1h4l.jpg|left|200px]]
{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }}
{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }}
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Cdk5 means Cyclin-dependent kinase 5. This protein could form a complex with p25, an other protein.<ref>doi:10.1007/s00894-009-0629-4</ref>
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CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.<ref>doi:10.1007/s00894-009-0629-4</ref>
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Cyclin dependent kinase 5 (CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility.
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CDK5 could form a complex with p25, an other protein.
==Structure==
==Structure==
===Sequence similarities===
===Sequence similarities===
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The chains A and B of the Cdk5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator.
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The chains A and B of the CDK5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator (p35).
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==Applications of Cdk5-p25 complex==
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==Applications of CDK5-p25 complex==
==Biology==
==Biology==
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=== Cdk5-p25 complex Control ===
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=== CDK5-p25 complex Control ===
==References==
==References==
<references />
<references />

Revision as of 18:39, 22 December 2011


Contents

CDK5-p25 complex

PDB ID 1h4l

Drag the structure with the mouse to rotate
1h4l, resolution 2.65Å ()
Related: 1lfr
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.[1] Cyclin dependent kinase 5 (CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility.

CDK5 could form a complex with p25, an other protein.

Structure

Sequence similarities

The chains A and B of the CDK5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator (p35).

Applications of CDK5-p25 complex

Biology

CDK5-p25 complex Control

References

  1. ↑ Zhang B, Su ZC, Tay TE, Tan VB. Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations. J Mol Model. 2010 Jun;16(6):1159-68. Epub 2009 Dec 15. PMID:20013135 doi:10.1007/s00894-009-0629-4
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