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Revision as of 18:54, 22 December 2011

CDK5-p25 complex

spinqualitylabelsall models PDB ID 1h4l Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1h4l, resolution 2.65Å ()
Related:	1lfr
Structural annotation: Resources: CATH : 1H4La02, 1H4La01, 1H4Lb01, 1H4Lb02, 1H4Ld00, 1H4Le00 InterPro : Ipr008271, Ipr011009, Ipr000719, Ipr002290, Ipr013763, Ipr004944, Ipr011028 Pfam : PF00069, PF03261 SCOP : d1h4la_, d1h4lb_, d1h4ld_, d1h4le_ UniProt : Q00535, Q15078
Functional annotation: Cellular component: nucleus dendrite growth cone cell soma neuromuscular junction lamellipodium cell projection membrane cytosol axon cytoplasm filopodium dendritic spine cyclin-dependent protein kinase 5 activator complex contractile fiber Biological process: neuron differentiation cell migration embryonic development axonogenesis neurite development cell division cell proliferation protein amino acid phosphorylation regulation of cell migration positive regulation of neuron apoptosis cell cycle cell-matrix adhesion neuron migration ionotropic glutamate receptor signaling pathway brain development neuron adhesion regulation of cyclin-dependent protein kinase activity axon guidance regulation of neuron differentiation axonal fasciculation acetylcholine receptor signaling, muscarinic pathway Molecular function: ErbB-3 class receptor binding cyclin-dependent protein kinase activity ATP binding nucleotide binding transferase activity protein binding ErbB-2 class receptor binding protein kinase activity acetylcholine receptor activator activity kinase activity tau-protein kinase activity protein serine/threonine kinase activity cadherin binding calcium ion binding cyclin-dependent protein kinase 5 activator activity protein serine/threonine kinase activator activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

CDK means Cyclin Dependent Kinase. The cyclin-dependent kinases (CDKs) are a large family of serine–threonine kinases which control the eukaryotic cell cycle, when they are activated by the cyclin regulatory subunit. These kinases phosphorylate a very large number of protein in order to inactivate or activate them.^[1] Cyclin dependent kinase 5 (CDK5) is a unique member of CDK family members that is not activated by a cyclin. Instead it is activated by a kinase, p35 also named Cyclin-dependent kinase 5 activator. Unlike other CDKs, it plays a major role in cell communication, cell morphology and motility.

CDK5 could form a complex with p25, an other protein.

Structure

Sequence similarities

The of the CDK5-p25 complex share homologuous sequences with the cell division protein kinase 5 and the chains D and E with the cyclin-dependent kinase 5 activator (p35).

The subunit of the CDK5 shares also a very similar three-dimensional (3D) structure with CDK2.

Applications of CDK5-p25 complex

Biology

CDK5-p25 complex Control

References

1. ↑ Zhang B, Su ZC, Tay TE, Tan VB. Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations. J Mol Model. 2010 Jun;16(6):1159-68. Epub 2009 Dec 15. PMID:20013135 doi:10.1007/s00894-009-0629-4