Sandbox 215
From Proteopedia
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==Structure== | ==Structure== | ||
| - | <Structure load='2OBD' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
==CETP inhibition== | ==CETP inhibition== | ||
Revision as of 13:41, 24 December 2011
Contents |
Cholesteryl Ester Transfer Protein (CETP)
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| 2obd, resolution 2.10Å () | |||||||||
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| Ligands: | , , , , , , , | ||||||||
| Gene: | CETP (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Introduction
Cholesteryl Ester Transfer Protein is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2-Å resolution in complex with four bound lipid molecules shows a long tunnel which traverses the core of the molecule and has two distinct large openings allowing lipid access. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end.
