1gpw
From Proteopedia
(New page: 200px<br /> <applet load="1gpw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gpw, resolution 2.40Å" /> '''STRUCTURAL EVIDENCE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GPW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GPW OCA]]. | + | 1GPW is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with PO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: PO1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GPW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: histidine biosynthesis]] | [[Category: histidine biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:47:06 2007'' |
Revision as of 10:42, 30 October 2007
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STRUCTURAL EVIDENCE FOR AMMONIA TUNNELING ACROSS THE (BETA/ALPHA)8 BARREL OF THE IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE BIENZYME COMPLEX.
Overview
Since reactive ammonia is not available under physiological conditions, glutamine is used as a source for the incorporation of nitrogen in a, number of metabolic pathway intermediates. The heterodimeric ImGP synthase, that links histidine and purine biosynthesis belongs to the family of, glutamine amidotransferases in which the glutaminase activity is coupled, with a subsequent synthase activity specific for each member of the enzyme, family. Its X-ray structure from the hyperthermophile Thermotoga maritima, shows that the glutaminase subunit is associated with the N-terminal face, of the (beta alpha)(8) barrel cyclase subunit. The complex reveals a, putative tunnel for the transfer of ammonia over a distance of 25 A., Although ammonia tunneling has been reported for glutamine, ... [(full description)]
About this Structure
1GPW is a [Protein complex] structure of sequences from [Thermotoga maritima] with PO4 as [ligand]. Structure known Active Site: PO1. Full crystallographic information is available from [OCA].
Reference
Structural evidence for ammonia tunneling across the (beta alpha)(8) barrel of the imidazole glycerol phosphate synthase bienzyme complex., Douangamath A, Walker M, Beismann-Driemeyer S, Vega-Fernandez MC, Sterner R, Wilmanns M, Structure. 2002 Feb;10(2):185-93. PMID:11839304
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