2iw1
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2iw1.gif|left|200px]]<br /><applet load="2iw1" size=" | + | [[Image:2iw1.gif|left|200px]]<br /><applet load="2iw1" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2iw1, resolution 1.50Å" /> | caption="2iw1, resolution 1.50Å" /> | ||
'''CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS'''<br /> | '''CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2IW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with U2F as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:U2f Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2IW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=U2F:'>U2F</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:U2f+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IW1 OCA]. |
==Reference== | ==Reference== | ||
| Line 28: | Line 28: | ||
[[Category: udp-glucose]] | [[Category: udp-glucose]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:38:49 2008'' |
Revision as of 08:38, 3 February 2008
|
CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS
Overview
Glycosyltransferases (GTs) catalyze the synthesis of the myriad, glycoconjugates that are central to life. One of the largest families is, GT4, which contains several enzymes of therapeutic significance, exemplified by WaaG and AviGT4. WaaG catalyses a key step in, lipopolysaccharide synthesis, while AviGT4, produced by Streptomyces, viridochromogenes, contributes to the synthesis of the antibiotic, avilamycin A. Here we present the crystal structure of both WaaG and, AviGT4. The two enzymes contain two "Rossmann-like" (beta/alpha/beta), domains characteristic of the GT-B fold. Both recognition of the donor, substrate and the catalytic machinery is similar to other retaining GTs, that display the GT-B fold. Structural information is discussed with, respect to the evolution of GTs and the therapeutic significance of the, two enzymes.
About this Structure
2IW1 is a Single protein structure of sequence from Escherichia coli with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4., Martinez-Fleites C, Proctor M, Roberts S, Bolam DN, Gilbert HJ, Davies GJ, Chem Biol. 2006 Nov;13(11):1143-52. PMID:17113996
Page seeded by OCA on Sun Feb 3 10:38:49 2008
