1wgi
From Proteopedia
(New page: 200px<br /> <applet load="1wgi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wgi, resolution 2.20Å" /> '''STRUCTURE OF INORGA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1WGI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WGI OCA]]. | + | 1WGI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1]]. Structure known Active Site: . Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WGI OCA]]. |
==Reference== | ==Reference== | ||
The structural basis for pyrophosphatase catalysis., Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A, Structure. 1996 Dec 15;4(12):1491-508. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8994974 8994974] | The structural basis for pyrophosphatase catalysis., Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A, Structure. 1996 Dec 15;4(12):1491-508. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8994974 8994974] | ||
| + | [[Category: Inorganic diphosphatase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pyrophosphate phosphohydrolase]] | [[Category: pyrophosphate phosphohydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:47:22 2007'' |
Revision as of 10:42, 30 October 2007
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STRUCTURE OF INORGANIC PYROPHOSPHATASE
Overview
BACKGROUND: Soluble inorganic pyrophosphatase (PPase), an essential enzyme, central to phosphorus metabolism, catalyzes the hydrolysis of the, phosphoanhydride bond in inorganic pyrophosphate. Catalysis requires, divalent metal ions which affect the apparent pKas of the essential, general acid and base on the enzyme, and the pKa of the substrate. Three, to five metal ions are required for maximal activity, depending on pH and, enzyme source. A detailed understanding of catalysis would aid both in, understanding the nature of biological mechanisms of phosphoryl transfer, and in understanding the role of divalent cations. Without a, high-resolution complex structure such a model has previously been, unobtainable. RESULTS: We report the first two high-resolution structures, of yeast PPase, ... [(full description)]
About this Structure
1WGI is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with MN as [ligand]. Active as [Inorganic diphosphatase], with EC number [3.6.1.1]. Structure known Active Site: . Full crystallographic information is available from [OCA].
Reference
The structural basis for pyrophosphatase catalysis., Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A, Structure. 1996 Dec 15;4(12):1491-508. PMID:8994974
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