2j0a
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2j0a.jpg|left|200px]]<br /><applet load="2j0a" size=" | + | [[Image:2j0a.jpg|left|200px]]<br /><applet load="2j0a" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2j0a, resolution 1.80Å" /> | caption="2j0a, resolution 1.80Å" /> | ||
'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE'''<br /> | '''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2J0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with SO4 and K as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222] Known structural/functional Site: <scene name='pdbsite=AC1:K Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2J0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222] Known structural/functional Site: <scene name='pdbsite=AC1:K+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J0A OCA]. |
==Reference== | ==Reference== | ||
| Line 31: | Line 31: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:40:06 2008'' |
Revision as of 08:40, 3 February 2008
|
STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
Overview
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify, Notch receptors, altering their ligand-binding specificity to regulate, Notch signaling in development. We present the crystal structure of mouse, Manic Fringe bound to UDP and manganese. The structure reveals amino acid, residues involved in recognition of donor substrates and catalysis, and a, putative binding pocket for acceptor substrates. Mutations of several, invariant residues in this pocket impair Fringe activity in vivo.
About this Structure
2J0A is a Single protein structure of sequence from Mus musculus with and as ligands. Active as O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, with EC number 2.4.1.222 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258
Page seeded by OCA on Sun Feb 3 10:40:06 2008
Categories: Mus musculus | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | Single protein | Chen, Y.W. | Clausen, H. | Cohen, S.M. | Conti, E. | Jinek, M. | K | SO4 | Developmental protein | Glycoprotein | Glycosyltransferase | Golgi apparatus | Membrane | Notch signaling | Signal-anchor | Transferase | Transmembrane
