1exf
From Proteopedia
(New page: 200px<br /> <applet load="1exf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1exf, resolution 2.1Å" /> '''EXFOLIATIVE TOXIN A'...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1EXF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] and [[http://en.wikipedia.org/wiki/Unidentified Unidentified]] with GLY as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA]]. | + | 1EXF is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] and [[http://en.wikipedia.org/wiki/Unidentified Unidentified]] with GLY as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EXF OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: superantigen]] | [[Category: superantigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:47:51 2007'' |
Revision as of 10:43, 30 October 2007
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EXFOLIATIVE TOXIN A
Overview
Exfoliative toxin A (ETA) causes staphylococcal scalded skin syndrome, which is characterized by a specific intraepidermal separation of layers, of the skin. The mechanism by which ETA causes skin separation is unknown, although protease or superantigen activity has been implicated. The X-ray, crystal structure of ETA has been solved in two crystal forms to 2.1 and, 2.3 A resolution and R-factors of 17% and 19%, respectively. The, structures indicate that ETA belongs to the chymotrypsin-like family of, serine proteases and cleaves substrates after acidic residues. The, conformation of a loop adjacent to the catalytic site is suggested to be, key in regulating the proteolytic activity of ETA through controlling, whether the main chain carbonyl group of Pro192 occupies the oxyanion, hole. A ... [(full description)]
About this Structure
1EXF is a [Single protein] structure of sequence from [Staphylococcus aureus] and [Unidentified] with GLY as [ligand]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease., Vath GM, Earhart CA, Rago JV, Kim MH, Bohach GA, Schlievert PM, Ohlendorf DH, Biochemistry. 1997 Feb 18;36(7):1559-66. PMID:9048539
Page seeded by OCA on Tue Oct 30 12:47:51 2007
