This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1dic
From Proteopedia
(New page: 200px<br /> <applet load="1dic" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dic, resolution 1.8Å" /> '''STRUCTURE OF 3,4-DIC...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1DIC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with DIC and O as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DIC OCA]]. | + | 1DIC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with DIC and O as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Complement_factor_D Complement factor D]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46]]. Structure known Active Site: S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DIC OCA]]. |
==Reference== | ==Reference== | ||
Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9757085 9757085] | Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9757085 9757085] | ||
| + | [[Category: Complement factor D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 25: | Line 26: | ||
[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:48:04 2007'' |
Revision as of 10:43, 30 October 2007
|
STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D
Overview
Factor D (D) is a serine protease essential in the activation of the, alternative complement pathway. Only a few of the common serine protease, inhibitors inhibit D, binding covalently to the serine hydroxyl of the, catalytic triad. 3,4-Dichloroisocoumarin (DCI) is a mechanism-based, inhibitor which inhibits most serine proteases and many esterases, including D. The structure of the enzyme:inhibitor covalent adduct of D, with DCI, DCI:D, to a resolution of 1.8 A is described, which represents, the first structural analysis of D with a mechanism-based inhibitor. The, side chain of the ring-opened DCI moiety of the protein adduct undergoes, chemical modification in the buffered solution, resulting in the formation, of an alpha-hydroxy acid moiety through the nucleophilic substitution of, ... [(full description)]
About this Structure
1DIC is a [Single protein] structure of sequence from [Homo sapiens] with DIC and O as [ligands]. Active as [Complement factor D], with EC number [3.4.21.46]. Structure known Active Site: S1. Full crystallographic information is available from [OCA].
Reference
Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:9757085
Page seeded by OCA on Tue Oct 30 12:48:04 2007
Categories: Complement factor D | Homo sapiens | Single protein | Babu, Y.S. | Chu, N. | Cole, L.B. | Kilpatrick, J.M. | DIC | O | Complement | Factor d | Hydrolase | Serine protease
