1dic
From Proteopedia
(New page: 200px<br /> <applet load="1dic" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dic, resolution 1.8Å" /> '''STRUCTURE OF 3,4-DIC...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1DIC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with DIC and O as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DIC OCA]]. | + | 1DIC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with DIC and O as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Complement_factor_D Complement factor D]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46]]. Structure known Active Site: S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DIC OCA]]. |
==Reference== | ==Reference== | ||
Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9757085 9757085] | Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9757085 9757085] | ||
| + | [[Category: Complement factor D]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:48:04 2007'' |
Revision as of 10:43, 30 October 2007
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STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D
Overview
Factor D (D) is a serine protease essential in the activation of the, alternative complement pathway. Only a few of the common serine protease, inhibitors inhibit D, binding covalently to the serine hydroxyl of the, catalytic triad. 3,4-Dichloroisocoumarin (DCI) is a mechanism-based, inhibitor which inhibits most serine proteases and many esterases, including D. The structure of the enzyme:inhibitor covalent adduct of D, with DCI, DCI:D, to a resolution of 1.8 A is described, which represents, the first structural analysis of D with a mechanism-based inhibitor. The, side chain of the ring-opened DCI moiety of the protein adduct undergoes, chemical modification in the buffered solution, resulting in the formation, of an alpha-hydroxy acid moiety through the nucleophilic substitution of, ... [(full description)]
About this Structure
1DIC is a [Single protein] structure of sequence from [Homo sapiens] with DIC and O as [ligands]. Active as [Complement factor D], with EC number [3.4.21.46]. Structure known Active Site: S1. Full crystallographic information is available from [OCA].
Reference
Structure of 3,4-dichloroisocoumarin-inhibited factor D., Cole LB, Kilpatrick JM, Chu N, Babu YS, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):711-7. PMID:9757085
Page seeded by OCA on Tue Oct 30 12:48:04 2007
Categories: Complement factor D | Homo sapiens | Single protein | Babu, Y.S. | Chu, N. | Cole, L.B. | Kilpatrick, J.M. | DIC | O | Complement | Factor d | Hydrolase | Serine protease
