4a55

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-	'''Unreleased structure'''	+	[[Image:4a55.jpg|left|200px]]
-	The entry 4a55 is ON HOLD	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_4a55", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_4a55| PDB=4a55 | SCENE= }}
-	Authors: Hon, W.-C., Berndt, A., Williams, R.L.	+	===Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108===
-	Description: Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22120714}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22120714 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22120714}}
		+
		+	==About this Structure==
		+	[[4a55]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A55 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022120714</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mus musculus]]
		+	[[Category: Berndt, A.]]
		+	[[Category: Hon, W C.]]
		+	[[Category: Williams, R L.]]
		+	[[Category: Cancer mutation]]
		+	[[Category: Enzyme regulation]]
		+	[[Category: Growth factor signalling]]
		+	[[Category: Lipid kinase]]
		+	[[Category: Membrane binding]]
		+	[[Category: Non-atp competitive ligand binding site]]
		+	[[Category: Oncogene]]
		+	[[Category: Pi3-kinase inhibitor]]
		+	[[Category: Structure-activity relationship]]
		+	[[Category: Transferase]]
		+	[[Category: Tumour]]

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Revision as of 07:23, 28 December 2011

Template:STRUCTURE 4a55

Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108

Template:ABSTRACT PUBMED 22120714

About this Structure

4a55 is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

• Hon WC, Berndt A, Williams RL. Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases. Oncogene. 2011 Nov 28. doi: 10.1038/onc.2011.532. PMID:22120714 doi:10.1038/onc.2011.532