2j96
From Proteopedia
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| - | [[Image:2j96.gif|left|200px]]<br /><applet load="2j96" size=" | + | [[Image:2j96.gif|left|200px]]<br /><applet load="2j96" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2j96, resolution 2.25Å" /> | caption="2j96, resolution 2.25Å" /> | ||
'''THE E-CONFIGURATION OF ALFA-PHYCOERYTHROCYANIN'''<br /> | '''THE E-CONFIGURATION OF ALFA-PHYCOERYTHROCYANIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2J96 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mastigocladus_laminosus Mastigocladus laminosus] with PVN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pvn Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2J96 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mastigocladus_laminosus Mastigocladus laminosus] with <scene name='pdbligand=PVN:'>PVN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pvn+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J96 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: z- to e-isomerization]] | [[Category: z- to e-isomerization]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:43:04 2008'' |
Revision as of 08:43, 3 February 2008
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THE E-CONFIGURATION OF ALFA-PHYCOERYTHROCYANIN
Overview
Phycobiliproteins and phytochromes are light-harvesting and light-sensing, proteins containing linear tetrapyrroles, so-called bile chromophores. The, chromophores in certain biliproteins, including the phytochromes, isomerize reversibly from a stable Z-configuration to a stable, E-configuration when irradiated with light of the appropriate wavelength., Here, we report the crystal structure of alpha-phycoerythrocyanin with its, chromophore in the E-configuration, compare it with the Z-configuration, found in trimeric phycoerythrocyanin, and reveal the structural bases of, the isomerization. The geometric changes of the chromophore account for, the large spectral shift, which characterizes the overall transition., Interactions of the chromophore A and D pyrrole rings with flexible, protein moieties are required for the formation and stabilization of the, isomers. We predict that the results will hold for all photoactive, biliproteins.
About this Structure
2J96 is a Single protein structure of sequence from Mastigocladus laminosus with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis for the photochemistry of alpha-phycoerythrocyanin., Schmidt M, Patel A, Zhao Y, Reuter W, Biochemistry. 2007 Jan 16;46(2):416-23. PMID:17209552
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